GROW Baby: Improving Maternal Gestational Weight Gain and Infant Growth in the Growing Right Onto Wellness (GROW) Trial

 描述(由申请人提供)：孕妇孕期体重增加(GWG)和婴儿体重快速增加是儿童终身肥胖风险的重要决定因素。在拉美裔人群中改善这些结果尤其重要，因为拉美裔人群的肥胖率及其相关的共病发生率高于普通人群。拟议的研究(成长婴儿)将测试行为干预如何支持健康的母亲GWG(目标1)和健康的婴儿成长(目标2)。通过从正在进行的名为Growth Right to Wellness(Growth)的随机健康生活方式试验中开发一个嵌套的子队列，Growth Baby将从怀孕的拉丁裔妇女和她们在研究期间出生的婴儿收集新的数据。Growth是一种根据文化定制的干预措施，向母亲和学龄前儿童(3-5岁)传授健康营养和体育活动。控制条件是入学准备计划。因为在研究期间怀孕的干预组母亲在怀孕之前或怀孕早期学习了这些健康的生活方式技能，所以干预具有 有潜力支持健康的产妇全球工作组和未来的婴儿成长。一位忠诚的初级导师和一个多学科的联合导师团队将监督候选人成为一名独立资助的内科科学家的过程，专注于利用怀孕期间健康的行为变化来预防和治疗母婴肥胖。职业发展计划包括行为干预、社区参与方法、母婴互动和针对服务不足人群的有针对性的方法等方面的高级培训。候选人将接触到在行为试验和围产期营养方面具有专业知识的资深导师，并将参与1)高级课程工作；2)预防儿童肥胖的持续干预；3)社区参与活动；以及4)多管齐下的方法，将文化敏感性技能应用于拉美裔人口的社区研究。在进行这项拟议的研究时，候选人将通过了解怀孕前和怀孕期间实施的行为干预如何支持母亲和孩子的健康体重来推动母婴肥胖预防领域的发展。

 DESCRIPTION (provided by applicant): Maternal gestational weight gain (GWG) and rapid infant weight gain are important determinants of a child's lifelong risk of obesity. It is particulrly important to improve these outcomes in the Latino population, where rates of obesity and its associated comorbidities are higher than in the general population. The proposed study (GROW Baby) will test how a behavioral intervention supports healthy maternal GWG (Aim 1) and healthy infant growth (Aim 2). By developing a nested sub-cohort from an ongoing randomized healthy lifestyle trial known as Growing Right Onto Wellness (GROW), GROW Baby will collect new data from both Latina women who become pregnant and their infants born during the study. GROW is a culturally tailored intervention that teaches healthy nutrition and physical activity for both mother and pre-school child (aged 3-5 years). The control condition is a school readiness program. Because intervention-group mothers who become pregnant during the study learn these healthy lifestyle skills prior to or early in pregnancy, the intervention has the potential to support healthy maternal GWG and future infant growth. A committed primary mentor and a multidisciplinary team of co-mentors will oversee the candidate's progression to becoming an independently funded physician scientist with a focus on leveraging healthy behavior changes during pregnancy to prevent and treat maternal and child obesity. The career development plan integrates advanced training in behavioral interventions, community engagement methods, the maternal- child interaction, and targeted approaches to underserved populations. The candidate will gain exposure to senior mentors with expertise in behavioral trials and perinatal nutrition, and will participate in 1) advanced coursework; 2) an ongoing intervention to prevent pediatric obesity; 3) community engagement activities; and 4) a multi-pronged approach applying cultural sensitivity skills to community research with Latino populations. In conducting the proposed research, the candidate will advance the field of maternal-child obesity prevention by understanding how a behavioral intervention implemented before and during pregnancy could support healthy weight for both mother and child.