Superfund Research Program at Boston University

项目概要/摘要 该应用程序包括五个跨学科的科学项目和五个核心建议，从一个经验丰富的 协作，利用两个主要的研究机构，波士顿大学（BU）的广泛资源 和伍兹霍尔海洋研究所。BU超级基金研究计划（BUSRP） 主要集中在新贝德福德港超级基金场地及其周围和饮用水中发现的污染物 在Buzzard's Bay和Cape Cod地区的社区水。NBH，一个18,000英亩的河口超级基金 多氯联苯含量极高（历史上沉积物中高达100毫克/克; 以及对周围社区和联邦有重大影响的其他工业废物， 正在尝试补救的国家机构。将所有组成部分联系在一起的主题是： 人类和野生动物在生命早期接触超级基金化学品"是一个特别感兴趣的新兴领域， NIEHS，USEPA和其他监管机构，部分原因是对新认识的影响 超级基金化学品暴露的结果，包括跨代影响和异常的青少年行为。 BUSRP的首要目标是在满足明确的具体目标的同时， 国家SRP。该计划有四个具体目标：1）开展多学科的人类和野生动物 基于人群的研究与动物模型中的机制研究相结合。这一目标涉及战略调整方案 任务是执行"机制和/或行动模式研究，包括实验室和人口- 基础研究”。两项补充性流行病学研究、三项实验室/实地项目和一项 支持服务的核心是解决早期生活暴露对青少年和成年人行为的影响， 发育中的生物系统（骨骼、脂肪组织、大脑）的完整性，以及基因编程或 几代人之间的基因库选择，所有新出现的环境健康问题。2)传播科学成果 通过双向伙伴关系向受影响社区提供援助。中央选举委员会将扩大和加强其以信任为基础， 通过有针对性的沟通战略与合作伙伴和利益攸关方建立双向关系， 鼓励开放获取，共享科学信息和资源。3)回应并提醒科学家 与政府利益攸关方合作，解决受影响社区最关心的环境问题。RTC， 与CEC，研究人员和受训人员一起，将提供科学专业知识，以应对 NBH/Buzzard's Bay/Cape Cod地区，扩大教育举措，制定预防和干预措施 战略，并协调多方向的公共和政府赞助的互动。4)火车和 指导年轻的研究人员在跨学科和跨学科的方法，以解决复杂的人类和 暴露于有害物质导致的生态健康问题。培训核心将实施一项 计划利用BU和WHOI内的资源，提供跨学科培训和指导， 向受训人员传授如何向简化登记方案伙伴和利益攸关方通报调查结果。

Program Summary / Abstract This application consists of five interdisciplinary scientific project and five core proposals from an experienced collaborative that leverages the extensive resources of two major research institutions, Boston University (BU) and the Woods Hole Oceanographic Institution (WHOI). The BU Superfund Research Program (BUSRP) focuses primarily on contaminants found in and around the New Bedford Harbor Superfund site and in drinking water of communities in the Buzzard's Bay and Cape Cod area. NBH, an 18,000 acre estuarine Superfund site, has extremely high levels of PCBs (historically up to 100 mg/g in sediment; 0.1-1 mg/g dry weight in killifish) and other industrial wastes of significant concern to the surrounding communities and to federal and state agencies who are attempting remediation. The theme that links all components, “Long-term impacts of early life exposure to Superfund chemicals in humans and wildlife,” is an emerging area of special interest to the NIEHS, USEPA, and other regulatory agencies in part because of the implications for newly appreciated Superfund chemical exposure outcomes, including transgenerational effects and aberrant adolescent behavior. The BUSRP's overarching objective is to address the Program theme while meeting specific goals articulated by the national SRP. The Program has four specific aims: 1) Carry out multidisciplinary human and wildlife population-based research integrated with mechanistic studies in animal models. This aim addresses the SRP mandate to perform “mechanistic and/or mode of action research that includes laboratory-and population- based studies.” Two complementing epidemiological studies, three laboratory/field-based projects, and a supporting service core address the effects of early life exposure on adolescent and adult behavior, the integrity of developing biologic systems (bone, adipose tissue, brain), and alterations in gene programming or gene pool selection across generations, all emerging environmental health issues. 2) Transmit scientific results to affected communities through bidirectional partnerships. The CEC will expand and enhance its trust-based, bidirectional relationships with partners and stakeholders through targeted communication strategies, encouraging open access, and sharing scientific information and resources. 3) Respond to and alert scientists and government stakeholders to environmental issues of most concern to affected communities. The RTC, with the CEC, investigators, and trainees, will provide scientific expertise in response to concerns in the NBH/Buzzard's Bay/Cape Cod area, expanding educational initiatives, developing prevention and intervention strategies, and coordinating multidirectional public and government sponsored interactions. 4) Train and mentor young investigators in inter- and transdisciplinary approaches to resolving complex human and ecological health issues resulting from exposure to hazardous substances. The Training Core will implement a program leveraging resources within BU and WHOI to provide interdisciplinary training and mentoring and to teach trainees how to communicate findings to SRP partners and stakeholders.