Hematopoiesis Training Grant

描述(申请人提供)：本申请书要求续期造血培训补助金，该基金成立于1999年，旨在解决对造血和造血干细胞生物学有职业兴趣的科学家和内科科学家培训机会不足的问题；并为下一代在这一不断发展的学科中提供核心科学领导。造血计划是一个多学科、跨部门的培训计划，利用宾夕法尼亚大学医学院(PSOM)、宾夕法尼亚儿童医院(CHOP)和维斯塔尔研究所的广泛资源；从注册参加其各种博士前和博士后计划的高素质学员池中挑选被任命的人员；并包括拥有广泛资金、出版物和指导成就的教员培训人员。造血计划已经培养了17名博士后和5名博士后科学家，拥有博士、医学博士或医学博士学位，目前还容纳了另外3名博士后和3名博士后。该计划吸引了来自PSOM大型且备受推崇的博士和医学博士项目的博士后候选人，以及来自PSOM和CHOP竞争性血液学奖学金项目的博士后申请者，以及来自全国各地领先实验室的博士后申请者。研究导师由24名科学和经验丰富的培训者提供，他们的研究兴趣几乎涵盖了造血的所有领域。该计划的学术要素包括课程作业、研讨会、实验室工作、指导和职业咨询、演示以及手稿和赠款撰写的综合课程，这些内容有效地结合在一起，培训新的研究人员造血科学的基础知识。学员的评估依据是书面和口头陈述、个性化发展计划以及与PI/PD以及研究和项目导师的状态会议。这一教学方法的成功体现在以下几个方面：受聘者已经晋升到学术界和工业界的领导职位，在项目毕业后成功获得资金，并对生物医学文献做出了重大贡献。2011年，在前一任PI/PD去世后，造血方案更换了领导层，促使对方案目标和政策进行了全面审查，这些目标和政策加强了培训经验，预计将影响未来的成果评估。审查还发现，宾夕法尼亚大学有一大批高素质的医学博士研究生，他们的职业兴趣是造血学；因此，本申请要求增加两个职位，专门用于这些合并学位的学生，以鼓励和支持他们在这一领域的职业发展。总而言之，造血计划是精心设计的，旨在培训个人的造血基础，目标是在这一重要且不断增长的人类生物学领域发展研究领导力。

DESCRIPTION (provided by applicant): This application requests a renewal of the Hematopoiesis Training Grant, which was founded in 1999 to address the shortage in training opportunities for scientists and physician-scientists with career interests in hematopoiesis and hematopoietic stem cell biology; and to provide a core scientific leadership in this growing discipline for the next generation. The Hematopoiesis Program is a multi-disciplinary, cross-departmental training program that capitalizes on the extensive resources of the University of Pennsylvania School of Medicine (PSOM), The Children's Hospital of Pennsylvania (CHOP), and the Wistar Institute; selects appointees from pools of highly qualified trainees enrolled in their various pre- and post-doctoral programs; and encompasses faculty trainers with extensive funding, publication, and mentoring achievements. The Hematopoiesis Program has trained 17 post-doctoral and 5 pre-doctoral scientists with PhD, MD, or MD-PHD degrees, and currently accommodates an additional 3 post-doctoral and 3 pre-doctoral appointees. The Program draws pre-doctoral candidates from the large and highly regarded PhD and MD-PhD programs at the PSOM; and post-doctoral applicants from the competitive hematology fellowship programs at PSOM and CHOP, and from leading laboratories throughout the nation. Research mentorship is provided by 24 scientifically and experientially diverse trainers with research interests that encompass virtually all areas of hematopoiesis. The academic elements of the Program include an integrated curriculum of coursework, seminars, laboratory work, mentoring and career counseling, presentation, and manuscript and grant writing, which are effectively combined to train new investigators in the fundamentals of hematopoiesis science. Trainees are evaluated on the basis of written and oral presentations, Individualized Development Plans, and status conferences with the PI/PD and both research and Program mentors. The success of this instructional approach is indicated by the number of appointees who have progressed to leadership positions in academia and industry, have been successfully funded following Program graduation, and have made significant contributions to the biomedical literature. The Hematopoiesis Program underwent a change in leadership in 2011 following the death of its previous PI/PD, prompting a comprehensive review of programmatic goals and policy that have strengthened the training experience and are expected to impact future outcomes evaluation. The review also identified a large pool of highly qualified pre-doctoral MD-PhD students at Penn with career interests in hematopoiesis; consequently, this application requests two additional positions that are dedicated to these combined-degree students, to encourage and support their career progression in this area. In sum, the Hematopoiesis Program is carefully designed to train individuals in the fundamentals of hematopoiesis, with a goal of developing research leadership in this important and growing area of human biology.