Project 1

项目1的重点是整合由不同分子种类组成的不同层次的信息，并在不同的时间尺度上运行的基本挑战。特别是，两个模型系统（酵母菌和盐杆菌）将被利用来开发的原则和规则，了解如何从环境中传播的信息，以协调多种反应和复杂的表型的理解方法。 我们将使用跨信号传导、基因调节和代谢网络的模型。通过该项目开发的工具和见解将适用于所有生物系统 发育、生理和结构。 此外，信号传导过程的故障导致表型和代谢异常。 人类疾病的潜在变化，包括癌症、神经病、肌病 和糖尿病了解这些网络的动态本质是一个窗口， 了解疾病状态和有效干预的合理策略 医学系统观的基础。

Project 1 focuses on the fundamental challenge of integrating different levels of information comprising different molecular species and operating across different time scales. In particular, two model systems (yeast and halobacterium) will be exploited to develop approaches for understanding the principles and rules governing how information from the environment is propagated to coordinate multiple responses and complex phenotypes. We will use models that traverse across signaling, gene regulatory and metabolic networks. Tools and insights developed through this project will be applicable to all biological system developmental, physiological and structural. Moreover, the malfunction of signaling processes leads to phenotypic and metabolic changes underlying human disease, including cancers, neuropathies, myopathies and diabetes. Understanding the dynamic nature of these networks is a window into understanding disease states and rational strategies for effective interventions the basis of a systems view of medicine.