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Characterizing Wnt Signaling Pathways in Axon Guidance

Characterizing Wnt Signaling Pathways in Axon Guidance
轴突引导中 Wnt 信号通路的特征
批准号：
9268077
负责人：
YIMIN ZOU
金额：
$41.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
项目状态：
已结题
起止时间：
2004-07-01 至 2019-04-30
来源：
https://reporter.nih.gov/project-details/9268077
关键词：
ADRBK1 geneAddressAdultAnteriorApicalAxonBiologicalBrainBrain StemCell CommunicationCell PolarityCell membraneCellsCuesDataDefectDevelopmentDiseaseDoseEndocytosisEpitheliumEquilibriumEventExcitatory SynapseFamilyFilopodiaFundingGeneticGrantGrowth ConesIndividualJournalsLabelLateralManuscriptsMedialMediatingModelingMonitorMosaicismMotor NeuronsNeurodegenerative DisordersNeurosciencesPHluorinPaperPhosphorylationPhosphotransferasesPositioning AttributeProteomicsRecyclingRetinal ConeRoleSeriesSignal PathwaySignal TransductionSpecific qualifier valueSpinal cord injurySystemTamoxifenTestingTextTherapeuticTissuesVesicleWNT Signaling PathwayWorkaxon growthaxon guidanceaxon regenerationaxonal degenerationdesignexperimental studyimprovedin vivoinhibitor/antagonistmorphogensneural circuitnovelplanar cell polaritypublic health relevancerepairedsuperoxide dismutase 1tooltrafficking

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中文摘要
翻译
描述（由申请人提供）：尽管已经鉴定了许多轴突导向分子，但导致定向轴突生长的信号传导和细胞生物学机制仍然知之甚少。在我们的进展的基础上，我们将深入探讨轴突引导的新信号传导和细胞生物学机制。具体来说，我们将使用Frizzled 3磷酸化和贩运作为工具，以解决如何在生长锥中产生信号不对称性以及参与转向的细胞生物学机制。我们还将使用遗传镶嵌方法来研究轴突-轴突相互作用，以解决一组轴突如何一起寻路的未回答的问题。
英文摘要
DESCRIPTION (provided by applicant): Although many axon guidance molecules have been identified, the signaling and cell biological mechanisms leading to directed axon growth are still poorly understood. Building on our progress, we will ask in-depth questions about novel signaling and cell biological mechanisms of axon guidance. Specifically, we will use Frizzled3 phosphorylation and trafficking as a tool to solve how signaling asymmetry is generated in the growth cone and the cell biological mechanisms involved in turning. We will also use genetic mosaic approaches to study axon-axon interactions to address the unanswered question of how a group of axons pathfind together.
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Characterizing Wnt Signaling Pathways in Axon Guidance
2021 Central Nervous System Injury and Repair Gordon Research Conference and Gordon Research Seminar
  • 批准号：
    10225691
  • 项目类别：
  • 资助金额：
    $1.2万
  • 财政年份：
    2021
  • 负责人：
    YIMIN ZOU
  • 依托单位：
    GORDON RESEARCH CONFERENCES
Signaling mechanisms for astrocyte polarization during glial scar formation after spinal cord injury
Combinatorial approaches to maximize axon regeneration after spinal cord injury
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