RR&D Research Career Scientist Award Application

摘要 罗伯特·L·莫克博士是一名研究健康科学家，也是翻译中心的联合主任 年，退伍军人下士迈克尔·J·克雷森茨医学中心肌肉骨骼研究中心 费城。他也是玛丽·布莱克·拉尔斯顿骨科教育和研究教授 宾夕法尼亚大学外科学和生物工程教授，以及 麦凯整形外科研究实验室。在宾夕法尼亚大学，莫克博士还担任 再生医学研究所(IRM)的肌肉骨骼再生计划，是 宾夕法尼亚大学肌肉骨骼疾病中心(PCMD)生物力学核心主任， 工程机械生物学中心(CEMB)创始成员。 莫克博士的研究计划侧重于肌肉骨骼的工程和机械生物学 对修复关节软骨、膝关节半月板和 腰间盘。Mauck博士的团队使用机械和分子分析来探索本地 组织结构功能关系，并利用这些信息来增强功能 通过专注于技术开发的工程结构的特性。他的作品探索了 祖细胞在各种生物材料环境中的功能和效能 尺度，从亚细胞生物物理特性到大型动物中工程结构的翻译 模特和人类。他的研究计划的目标是开发和部署新的再生能源 改善退伍军人和整个人群肌肉骨骼健康的疗法。 莫克博士得到了退伍军人事务部、美国国立卫生研究院、 国家科学基金会，以及几个基金会和私人组织。他是一名活跃分子 美国机械工程师学会(ASME)矫形外科研究会会员 美国组织工程与再生医学国际学会(ORS)， 生物医学工程学会(BMES)和国际软骨修复学会(ICRS)。 莫克博士是《脊柱矫形外科研究杂志》的联合主编，并在 《矫形外科研究杂志》编辑委员会，《机械行为》杂志 《生物医学材料》和《实验整形外科杂志》。他出版了&gt；190 手稿(被引用10400次)，摘要300篇，图书12章。 莫克博士因其在该领域的贡献而获得ISSLS生物力学奖 (2008)、ASME冯永强青年研究员奖(2009)、BMES-CMBE“后起之秀” 奖(2011)，宾夕法尼亚大学蒙塔古医学院研究奖(2013)，当选为 卡帕三角洲美国医学和生物工程学会院士(2014) 美国整形外科医生学会颁发的青年研究员奖(2015)，伯顿 拉恩研究奖，获得AO基金会(2017)，并被选为国际 国际骨科联合研究会的骨科研究(FIRE) (ICORs)研究员学院(2019年)。他最近还被选为“世界上最优秀的科学家” 年在CMC VAMC(2019年)。

Abstract Robert L. Mauck, PhD is a Research Health Scientist and Co-Director of the Translational Musculoskeletal Research Center at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia. He is also the Mary Black Ralston Professor of Education and Research in Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania, and the Director of the McKay Orthopaedic Research Laboratory. At Penn, Dr. Mauck also serves as the Co-Director of the Program in Musculoskeletal Regeneration in the Institute for Regenerative Medicine (IRM), is the Director of the Biomechanics Core of the Penn Center for Musculoskeletal Disorders (PCMD), and is a founding member of the Center for Engineering Mechanobiology (CEMB). Dr. Mauck’s research program is focused on the engineering and mechanobiology of musculoskeletal tissues, with a particular interest in restoring articular cartilage, the knee meniscus, and the intervertebral disc. Dr. Mauck’s team uses mechanical and molecular analyses to explore native tissue structure function relationships, and employs this information to enhance the functional properties of engineered constructs through focused technology development. His work explores progenitor cell function and efficacy in a variety of biomaterial contexts and across multiple length scales, from subcellular biophysical properties to translation of engineered constructs in large animal models and humans. The goal of his research program is to develop and deploy novel regenerative therapies to improve musculoskeletal health in Veterans and the population as a whole. Dr. Mauck is supported by the Department of Veterans Affairs, the National Institutes of Health, the National Science Foundation, and several foundations and private organizations. He is an active member of the American Society for Mechanical Engineers (ASME), the Orthopaedic Research Society (ORS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS), the Biomedical Engineering Society (BMES), and the International Cartilage Repair Society (ICRS). Dr. Mauck is the co-Editor-in-Chief of the Journal of Orthopaedic Research Spine and serves on the editorial board of the Journal of Orthopaedic Research, the Journal of the Mechanical Behavior of Biomedical Materials, and the Journal of Experimental Orthopaedics. He has published >190 manuscripts (cited >10400 times), >300 abstracts, and >12 book chapters. Dr. Mauck has been recognized for his contributions to the field with the ISSLS Prize in Biomechanics (2008), the YC Fung Young Investigator Award from the ASME (2009), the BMES-CMBE ‘Rising Star’ Award (2011), the Penn Medicine Montague Research Prize (2013), election to the College of Fellows of the American Institute for Medical and Biological Engineering (2014), the Kappa Delta Young Investigator Award from the American Academy of Orthopaedic Surgeons (2015), the Berton Rahn Research Award from the AO Foundation (2017), and was inducted as a Fellow of International Orthopaedic Research (FIOR) of the International Combined Orthopaedic Research Societies (ICORS) College of Fellows (2019). He was also recently selected as the ‘Research Scientist of the Year’ at the CMC VAMC (2019).