Training Program in Musculoskeletal Research

肌肉骨骼研究培训计划

• 批准号: 10861378
• 负责人: Robert L Mauck
• 金额: $ 5.38万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10861378
• 关键词: Musculoskeletal; Research; Training Programs

The purpose and objectives of the training program proposed for continued support remain to prepare bioengineers for an impactful career in orthopaedic research as part of a focused program leading to the Ph.D. degree in Bioengineering. Training a diverse cohort of bioengineers side-by-side with orthopaedic surgeons and life scientists at various levels of training, will continue to foster an environment conducive to research and education in the orthopaedic arena. Indeed, this has been the formula that has been very successful in our training program thus far and, in today's complex and interdisciplinary research world, this approach is more essential than ever. Trainee research areas represent a wide range of musculoskeletal problems including, but not limited to, the cellular and molecular biology of bone growth, repair, ossification, and maintenance; the etiology and pathogenesis of tendon and ligament injury, repair, and regeneration; mechanical loading effects on articular cartilage; and biomaterials to promote tissue repair and regeneration. In addition to formal didactic coursework outlined in our enhanced Orthopaedic Bioengineering curriculum, training opportunities include seminar series, journal clubs, and other enrichment and outreach activities. The primary participating departments in this training program are the Department of Orthopaedic Surgery in the Perelman School of Medicine and the Department of Bioengineering in the School of Engineering and Applied Science at the University of Pennsylvania. Both departments have grown significantly over the past five years in terms of numbers of faculty, grant funding, and trainees. Six predoctoral trainees are requested in this continuation grant. It should be noted that the predoctoral trainees work in a structured, yet flexible environment while completing course requirements toward the Ph.D. degree in Bioengineering. Despite the fact that the Ph.D. program is typically five years in total duration, typically, only two years, and not the first year, will be supported by this training grant so that positions can be made available for new trainees to grow the program. There are three primary training sites for this training grant. The first primary site is the McKay Orthopaedic Research Laboratory in Stemmler Hall in the Department of Orthopaedic Surgery, the second is the Translational Musculoskeletal Research Center at the Philadelphia VA Medical Center, and the third is the orthopaedic research unit in Skirkanich Hall in the Department of Bioengineering. These facilities represent >85% of the dedicated training space for the program. Finally, it should be noted that the University of Pennsylvania operates a large number of state-of-the-art, sophisticated core facilities that are available to faculty and trainees.

拟议继续提供支助的培训方案的目的和目标仍有待于准备 生物工程师在骨科研究的影响力职业生涯的一部分，导致博士学位的重点计划。 生物工程学位。与骨科医生并肩培养多样化的生物工程师队伍 将继续促进有利于研究的环境， 矫形竞技场的教育。事实上，这是一个在我们国家非常成功的公式。 培训计划迄今为止，在今天的复杂和跨学科的研究世界，这种方法是更多 比以往任何时候都重要。学员研究领域代表了广泛的肌肉骨骼问题，包括，但 不限于骨生长、修复、骨化和维持的细胞和分子生物学; 肌腱和韧带损伤、修复和再生的病因和发病机制;机械负荷效应 和促进组织修复和再生的生物材料。除了正式的说教之外， 课程概述在我们的增强骨科生物工程课程，培训机会包括 研讨会系列、期刊俱乐部以及其他丰富和推广活动。 本培训项目的主要参与科室为骨科 在佩雷尔曼医学院和生物工程系在工程学院和 宾夕法尼亚大学应用科学系。这两个部门在过去都有显著增长 五年的教师人数，赠款资金和学员。 这项继续资助需要六名博士前学员。值得注意的是， 学员在一个结构化的，但灵活的环境中工作，同时完成博士学位的课程要求。 生物工程学位。尽管事实上博士。该计划的总期限通常为五年， 通常情况下，只有两年，而不是第一年，将支持这一培训补助金，使职位可以 为新学员提供发展计划的机会。 有三个主要的培训地点可获得这一培训补助金。第一个主站点是McKay Orthopathy 骨科系Stemmler Hall的研究实验室，第二个是 费城退伍军人医疗中心的转化肌肉骨骼研究中心，第三个是 骨科研究单位在Skirkanich大厅在生物工程系。这些设施代表了 >85%的专用培训空间。最后，应该指出， 宾夕法尼亚州运营着大量最先进、先进的核心设施， 教师和实习生。

项目成果

Inter-subject FDG PET Brain Networks Exhibit Multi-scale Community Structure with Different Normalization Techniques.

• DOI: 10.1007/s10439-018-2022-x
• 发表时间: 2018-07
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Sperry MM;Kartha S;Granquist EJ;Winkelstein BA
• 通讯作者: Winkelstein BA

Cellular responses to chemical and morphologic aspects of biomaterial surfaces. I. A novel in vitro model system.

• DOI: 10.1002/jbm.820290909
• 发表时间: 1995-09
• 期刊: Journal of biomedical materials research
• 作者: K. Chesmel;Jonathan Black

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials.

• DOI: 10.1021/acsbiomaterials.7b00734
• 发表时间: 2017-12-11
• 期刊: ACS biomaterials science & engineering
• 影响因子: 5.8
• 作者: Chen MH;Wang LL;Chung JJ;Kim YH;Atluri P;Burdick JA
• 通讯作者: Burdick JA

Optimized Media Volumes Enable Homogeneous Growth of Mesenchymal Stem Cell-Based Engineered Cartilage Constructs.

优化的培养基体积使基于间充质干细胞的工程软骨结构能够均匀生长。

• DOI: 10.1089/ten.tea.2020.0123
• 发表时间: 2021
• 期刊: Tissue engineering. Part A
• 作者: Zlotnick,HannahM;Stoeckl,BrendanD;Henning,ElizabethA;Steinberg,DavidR;Mauck,RobertL
• 通讯作者: Mauck,RobertL

Human osteoblast-like cells in three-dimensional culture with fluid flow.

具有流体流动的三维培养中的人成骨细胞样细胞。

• 发表时间: 2003
• 期刊: Biorheology.
• 作者: Botchwey,EdwardA;Pollack,SolomonR;El-Amin,Saadiq;Levine,ElliotM;Tuan,RockyS;Laurencin,CatoT
• 通讯作者: Laurencin,CatoT