RTI CHEAR Exposure Assessment Hub

 说明(由申请人提供)：本申请是为响应RFA-ES-15-009：儿童健康暴露分析资源(CHEAR)：国家暴露评估实验室网络(U2C)而准备的，如果获得资助，将成为CHEAR的几个中心之一，旨在向流行病学和临床研究人员提供暴露评估标记测量和生物反应指标测量。RTI国际CHEAR中心的最终目标是开发一个自给自足的中心，它将保持和发展最先进的标准化方法，并促进在暴露和反应评估方面的研究、培训和教育。RTI CHEAR中心将在CHEAR网络内并与其他CHEAR中心、CHEAR数据仓库和分析科学中心(DRASC)和CHEAR协调中心(CC)合作，开发新方法；改进现有方法，以降低浓度和新的矩阵；就研究设计、样本收集和存储提供指导；并为定向、非定向和生物反应测量提供服务。本提案描述了将用于目标分析资源核心(TARC，领导者Keith Levine)、非目标分析资源核心(UARC，领导者Susan Sumner)和生物响应指标核心(BRIC，共同领导者Robert Clark和Leslie Recio)的能力、经验和方法。发展核心将改进现有方法并开发新的分析和生物学方法来评估环境暴露的影响(DC，领导Timothy Fennell)。行政核心将监督与CHEAR计划的互动，并将确保时间表、预算和人员配备适合进行研究。RTI在暴露评估方面有数十年的经验，并有进行儿童健康研究的历史。由Timothy Fennell博士指导的RTI CHEAR Hub得到了NIH东部区域综合代谢组学资源核心(RTI RCMRC，由Susan Sumner博士指导)的无针对性分析能力的加强，以及我们与Oliver Fiehn博士的合作伙伴关系，Oliver Fiehn博士是加州大学戴维斯分校西海岸RCMRC的负责人，他在进行大型队列研究的代谢组学方面经验丰富。我们在集成实验室系统的合作伙伴(由Leslie Recio博士指导)为生物响应指标的测量带来了更深入的优势。CHEAR计划的总体目标将是提供用于流行病学和临床调查的资源和服务，以便能够使用最先进的技术分析广泛的生物谱系，以了解环境对疾病的影响。

 DESCRIPTION (provided by applicant): This application is prepared in response to RFA-ES-15-009: Children's Health Exposure Analysis Resource (CHEAR): National Exposure Assessment Laboratory Network (U2C), and, if funded, will be one of several CHEAR Hubs designed to provide exposure assessment marker measurements and biological response indicator measurements to epidemiological and clinical investigators. The ultimate goal of the RTI International CHEAR Hub is to develop a self-sustaining Hub that will maintain and develop state-of-the- art standardized methods and promote research, training, and education in assessment of exposure and response. The RTI CHEAR Hub will work within the CHEAR Network and with other CHEAR Hubs, the CHEAR Data Repository and Analysis Science Center (DRASC), and the CHEAR Coordinating Center (CC) to develop new methods; to refine existing methods to lower concentrations and new matrices; to provide guidance on study design, sample collection, and storage; and to provide services for targeted, untargeted, and biological response measurements. This proposal provides a description of the capabilities, experiences, and approaches that will be used in the Targeted Analysis Resource Core (TARC, Leader Keith Levine), the Untargeted Analysis Resource Core (UARC, Leader Susan Sumner), and the Biological Response Indicator Core (BRIC, Co-Leaders Robert Clark and Leslie Recio). Refinement of existing methods and the development of new analytical and biological approaches to assess the impact of environmental exposure will be conducted by the Development Core (DC, Leader Timothy Fennell). The Administrative Core will provide oversight for interactions with the CHEAR Program and will ensure that timelines, budgets, and staffing are appropriate for the studies to be performed. RTI has decades of experience in exposure assessment and has a history of conducting research in children's health. The RTI CHEAR Hub, directed by Dr. Timothy Fennell, is strengthened by the untargeted analysis capabilities of the NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC, directed by Dr. Susan Sumner) and our partnership with Dr. Oliver Fiehn who directs the West Coast RCMRC at University of California at Davis and is experienced in conducting metabolomics for large cohort studies. Our partners at Integrated Laboratory Systems (Directed by Dr. Leslie Recio) bring additional in-depth strengths for the measurement of biological response indicators. The overall goal of the CHEAR Program will be to provide resources and services for use in epidemiological and clinical investigations to enable analysis of a wide range of biospecimens using state-of-the-art technologies to understand the influence of the environment on disease.