Genome Technology Center Shared Resource

摘要/项目摘要 基因组技术中心（GTC） 基因组技术中心（GTC）共享资源提供集中的专家基因组 为纽约大学朗格尼健康中心（NYULH）的所有Perlmutter癌症中心（PCC）研究人员提供服务。 在公认的基因组分析专家Adriana Heguy博士的指导下，GTC是一个 国家的最先进的，高通量，快速周转，设备齐全的基因组设施，专门从事 短读（Illumina）和长读（PacBio，Oxford Nanopore Technologies）深度 用于多种应用的测序和样品制备，包括RNASeq，ChIPSeq， ATACSeq、亚硫酸氢盐测序、单细胞测序、染色质构象测序 方法，以及许多其他方法。GTC的使命是通过以下方式促进跨机构科学 在协作环境中提供高度专业化的支持， 补助金申请和出版物。GTC提供负担得起的技术 先进的服务和仪器，以及教师，工作人员， 研究员和学生在PCC谁有兴趣了解这些技术如何可以 推进基础和临床癌症研究。GTC的具体目标是：目标1） 提供专家基因组服务;目标2）评估和实施新的基因组技术 目的3）促进数据共享和存储 通过高性能计算安全服务器;目标4）协助CLIA认证的NGS 技术开发和验证实验室;目标5）教育和告知成员 基因组技术及其在癌症研究中的应用。

Abstract/Project Summary GENOME TECHNOLOGY CENTER (GTC) The Genome Technology Center (GTC) shared resource provides centralized, expert genomic services to all Perlmutter Cancer Center (PCC) investigators at NYU Langone Health (NYULH). Under the direction of Dr. Adriana Heguy, a recognized expert in genomic analysis, GTC is a state-of-the-art, high throughput, fast turnaround, fully equipped genomic facility, specializing in both short-read (Illumina) and long-read (PacBio, Oxford Nanopore Technologies) deep sequencing and sample preparation for a variety of applications including RNASeq, ChIPSeq, ATACSeq, bisulfite sequencing, single cell sequencing, chromatin conformation sequencing approaches, and many others. The GTC mission is to foster cross-institutional science by providing highly specialized support in a collaborative environment that results in successful grant applications and publications. GTC provides affordable access to technologically advanced services and instrumentation, and an educational environment for faculty, staff, fellows, and students in the PCC who are interested in learning how these technologies can advance their basic and clinical cancer research. The Specific Aims of GTC are: Aim 1) To provide expert genomic services; Aim 2) To evaluate and implement novel genomic technology and thereby maintain state-of-the-art services; Aim 3) To facilitate data sharing and storage through high performance computing secure servers; Aim 4) To assist the CLIA-certified NGS laboratory in technology development and validation; Aim 5) To educate and inform members of the PCC communities on genomic technologies and their utility for cancer research.