Scientific Information Management and Literature-Based Evaluations for the NTP - Support for the Conduct of Systematic Reviews

NTP司根据有关人类接触的信息，对文献进行系统审查，以评估试剂、物质、混合物或暴露情景对人类健康的潜在不利影响。这些综述的结果通常集中在癌症或非癌症的影响上，并以专著形式出版。这些审查主要由dNTP综合健康评估处进行，并支持国会授权的致癌物报告(ORoC)。ORoC列出了对生活在美国的人构成癌症危险的物质，以及与物质的癌症危险评估相关的文件，作为报告中潜在的新清单。正在进行的系统评价包括氟化物、双酚A和炎症/动脉粥样硬化。 关键词：系统综述、毒理学、流行病学、暴露、癌症、非癌症影响

The Division of NTP performs systematic reviews of literature to assess the potential for adverse effects on human health by agents, substances, mixtures, or exposure scenarios, based on information about human exposure. The findings of these reviews generally focused on either cancer or non-cancer effects and published as monographs. These reviews are conducted primarily by the DNTP Integrative Health Assessment Branch and and in support of the congressionally mandated Report on Carcinogens (ORoC). The ORoC lists substances that pose a cancer hazard for people living in the United States, and documents related to the cancer hazard evaluation of substances as potential new listings in the report. Systematic reviews in progress include fluoride, bisphenol A, and inflammation/atherosclerosis. Keywords: Systematic review, toxicology, epidemiology, exposure, cancer, non-cancer effects