Filling a Void of Research (FAVOR) Training for Transplant Surgeons

项目摘要/摘要 题为《填补移植外科医生研究培训空白》的Four T32将为外科手术做准备 在腹部和胸部移植手术方面从事转化性研究的住院医生。这一计划将 培训和激励一支独特的外科医生-科学家干部队伍，将床边敏锐的观察转化为 手术室，并在临床上转化为新的假说，可以通过免疫学重点询问 翻译研究。该计划的重点是独特的，满足不断增长的需求，以培训下一代 移植外科医生-可以为新兴的翻译和个性化领域做出贡献的科学家 医药。有利的结构是为了扭转这一令人沮丧的趋势，导致只有1.8%的AST接受过外科培训 成功竞争NIH-K系列奖的研究员，尽管76%的人被激励花更多的时间在 研究(Engesbe等人，AJT 2010：10,191-193；Kirk&Fung，AJT 2011，11；191-193)。培训内容包括 基础课程，包括小说《T32宠爱沉浸研讨会》，以及 临床研究中的设计临床研究、统计计算和数据库管理 写作，以及临床研究的生物统计学方法。该优惠T32还包括专门的培训 将根据长期目标和兴趣为每个学员量身定做的选修课。一支小分队 来自加州大学旧金山分校的外科实习生，所有符合资格和高度多样化的培训补助金(约40%的URM，50%的女性)将 被选中以获得好感。我们亦会以竞争性申请方式，邀请其他学术机构的学员参加。 总计3个培训时段/年，受训人员将投入两年的全职时间，没有显著的临床意义 负责研究、教育和培训。一个实习生时段/年也有资格报名 参加1-2年临床/转化医学学位课程。受训者将准备将他们的培训应用于 为了加深对免疫系统的了解，以及开发基于免疫的新诊断方法， 与外科手术程序和结果相关的预后、治疗学和临床方法。而当 在该计划中，他们还将学习如何开发和利用结合外科手术的临床数据库 结果来自病理学和免疫学的数据。美国国立卫生研究院资助的教职员工，成绩斐然 免疫学和翻译研究的记录，已被特别挑选来激励和指导受训人员 翻译指导研究，从临床和科学领域各选出2名导师/实习生 导师池。培训后的职业建议和指导将有助于安排进入著名的奖学金 和学术教员职位，有利于实习生。优惠计划的全国影响将是 通过拥有全面临床专业知识的受训人员小组的科学成熟和 杰出的翻译科学，能够将翻译免疫学应用于器官移植 收件人。

PROJECT SUMMARY/ABSTRACT The FAVOR T32 titled “Filling a Void of Research Training for Transplant Surgeons” will prepare surgical residents for translational research careers in abdominal and thoracic transplant surgery. This program will train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research. This program is uniquely focused, serving a growing need to train the next generation of transplant surgeon-scientists that can contribute to the burgeoning field of translational and personalized medicine. FAVOR is structured to reverse the dismal trend resulting in only 1.8% of ASTS trained surgical fellows successfully competing for NIH-K series awards, despite 76% being motivated to spend more time in research (Englesbe et al., AJT 2010:10, 191-193; Kirk & Feng, AJT 2011, 11; 191-193). The training includes a base curriculum that includes a novel “T32 FAVOR Immersion Workshop,” as well as core courses in Designing Clinical Research, Statistical Computing and Database Management in Clinical Research, Scientific Writing, and Biostatistical Methods for Clinical Research. The FAVOR T32 also includes specialized training electives which will be tailored to each trainee based on long term goals and interests. A small cadre of surgical trainees from within UCSF, all training grant eligible and highly diverse (~40% URM, 50% female), will be selected for FAVOR. We will also invite trainees from other academic institutions by competitive application for a total of 3 training slots/ year, where trainees will dedicate two full-time years, without significant clinical responsibilities, towards research education and training. One trainee slot/year would also be eligible to enroll in a 1-2 year degree course in Clinical/Translational Medicine. Trainees will be prepared to apply their training to deepen understanding of the immune system, as well as developing new, immune-based diagnostics, prognostics, therapeutics and clinical approaches that are relevant to surgical procedures and outcomes. While in the program they will also learn how to develop and draw upon clinical databases that integrate surgical outcomes with data from pathology and immunology. FAVOR's NIH-funded faculty, with distinguished track records in immunology and translational research, have been specially selected to inspire and guide trainees in translational mentored research, with selection of 2 mentors/trainee from each of the clinical and scientific mentor pools. Post-training career advice and guidance will facilitate placement into prestigious fellowships and academic faculty positions for FAVOR trainees. The national impact of the FAVOR program will be realized through the scientific maturation of a trainee group with comprehensive clinical expertise and outstanding translational science, with the ability to apply translational immunology to benefit organ transplant recipients.