Radiochemistry Core

放射化学核心 放射化学核心的主要功能是执行良好生产程序（GMP） 综合开展支持试点项目的研究所需的所有放射性示踪剂。芯会 导演：Robert H.马赫博士马赫博士是宾州回旋加速器设施的主任， 在PET放射化学领域有多年的经验。Hsiaoju Lee，博士，宾州回旋加速器设备经理， 将监督该设施的日常运作。她有十多年的GMP生产经验 在过去的5年里，他一直与马赫博士密切合作。除此之外，经修订的 申请是耶鲁大学在这个P30中心的参与; P.I.放射化学成分， Yiyun（亨利）Huang博士是耶鲁PET中心的负责人，他开发了P30中心使用的Kappa放射性示踪剂。 除了PET放射性示踪剂的GMP生产外，放射化学中心还将负责 合成试点项目中所述研究所需的所有前体和HPLC标准品 这是商业来源所不能提供的。作为P30中心资源共享计划的一部分， 专有的前体和标准将与宾夕法尼亚大学以外的NIDA资助的研究人员共享， 加速阿片类药物使用障碍和神经炎症的神经生物学PET成像研究。一 放射化学核心的最后一个功能是对动脉血样进行代谢物分析， 数据分析组（由 博士理查德卡森，耶鲁大学PET中心）。

RADIOCHEMISTRY CORE The main function of the Radiochemistry Core is to conduct the Good Manufacturing Procedures (GMP) synthesis of all radiotracers needed to conduct the research in support of the pilot projects. The core will be directed by Robert H. Mach, Ph.D. Dr. Mach is the Director of the Penn Cyclotron Facility and has over thirty years of experience in the field of PET radiochemistry. Hsiaoju Lee, Ph.D., the Penn Cyclotron Facility Manager, will oversee the day-to-day operation of the facility. She has over ten years of experience in the GMP production of PET radiotracers and has worked closely with Dr. Mach for the past 5 years. An addition to this revised application is the involvement of Yale University in this P30 Center; the P.I. of the radiochemistry component for the Yale PET Center is Dr. Yiyun (Henry) Huang, who developed the kappa radiotracer used in this P30 Center. In addition to the GMP production of PET radiotracers, the Radiochemistry Core will be responsible for the synthesis of all precursors and HPLC standards that are required for the research described in the pilot projects that are not available from commercial sources. As part of the Resource Sharing Plan for this P30 Center, these proprietary precursors and standards will be shared with NIDA-funded investigators outside of Penn as a means of accelerating PET imaging research on the neurobiology of opiate use disorders and neuroinflammation. A final function of the Radiochemistry Core is to conduct the metabolite analysis of arterial blood samples from the PET imaging studies that is required for input function measurements by the data analysis group (directed by Dr. Richard Carson, Yale University PET Center).