Biostatistics and Bioinformatics

项目总结 生物统计和生物信息学共享资源核心2的目的是提供咨询和 在所有孢子项目、开发项目、管理核心和 共享资源核心1.项目领导人与生物统计学家和 这个孢子中的计算生物学家，以及其他核心的成员，对于实现 项目的目标。这个核心的成员将为设计、分析和报告提供支持 实验室、动物、翻译、基因组和临床研究。根据项目不同，这些协作 范围可能从短期磋商到大型合作项目，并将包括协助准备 批准与孢子项目相关的申请和稿件。核心成员还将提供 为研究人员提供统计和生物信息学指导，特别强调职业发展 获奖者和发展项目调查员。孢子的成功很重要的是配合 数据管理和质量控制程序。生物统计学家和计算生物学家是 这是新闻部这一进程的组成部分，并将继续提供对现有程序的投入以及 关于额外的计算基础设施的建议，这可能是这个孢子所必需的。至 为了实现孢子的目标，我们提出了以下具体目标： 具体目标1.为孢子项目提供计算生物学和生物信息学合作， 发展项目和核心。这包括设计、预处理、存储和分析所有高 吞吐量基因组研究。 具体目标2.为孢子项目、发展项目和 核心。这包括实验室和临床方案的设计、实施、分析和报告； 实验室结果与患者特征和临床研究结果的协调。 具体目标3.为孢子研究人员提供咨询和统计教育。培养严谨和 孢子中所有计算活动的重现性，核心也将提供或建议支持 用于数据收集、表格开发、数据处理和质量保证的计算基础设施 临床试验数据，以及在实验室、动物和相关临床研究的数据库之间移动数据。

PROJECT SUMMARY The purpose of the Biostatistics and Bioinformatics Shared Resource Core 2 is to provide consultation and collaboration on quantitative methods on all SPORE Projects, Developmental Projects, and Admin Core and Shared Resource Core 1. Successful collaboration between the project leaders and the biostatisticians and computational biologists in this SPORE, as well as members of the other Cores, is essential to achieve the goals of the projects. Members of this core will provide support for the design, analysis, and reporting of laboratory, animal, translational, genomic, and clinical studies. Depending on the project, these collaborations could range from short consultations to large collaborative projects, and will include assistance in preparation of grant applications and manuscripts related to the SPORE projects. The Core members will also provide statistical and bioinformatics mentoring to the researchers, with a particular emphasis on Career Development Awardees and Developmental Project Investigators. Important for the success of the SPORE is the coordination of data management and quality control procedures. The biostatisticians and computational biologists are an integral part of this process at the DFCI, and will continue to provide input on the existing procedures, as well as recommendations on additional computational infrastructure, which might be necessary for this SPORE. To achieve the goals of the SPORE, we propose the following specific aims: Specific Aim 1. To provide computational biology and bioinformatics collaboration for SPORE Projects, Developmental Projects, and Cores. This includes design, preprocessing, storage, and analysis of all high throughput genomic studies. Specific Aim 2. To provide biostatistical collaboration for SPORE Projects, Developmental Projects, and Cores. This includes design, conduct, analysis and reporting of laboratory and clinical protocols; including the coordination of laboratory results with patient characteristics and outcomes from the clinical studies. Specific Aim 3. To provide consulting and statistical education to SPORE researchers. To foster rigor and reproducibility of all computational activities in the SPORE, the core will also provide or recommend supporting computational infrastructure for data collection, form development, data processing, and quality assurance of clinical trials data, as well as moving data between databases for laboratory, animal, and relevant clinical studies.