Core 1: Administrative Core

SWAN-Aging旨在确定中年健康和更年期过渡（MT）特征对女性成功衰老的影响程度，包括认知能力下降的速度以及痴呆和残疾的风险。关于老龄化的研究强调中年（40-65岁）是预防认知障碍、阿尔茨海默病、与阿尔茨海默病有关的痴呆、身体残疾和老年多发病的关键生命阶段。这项U19提案将扩大全国妇女健康研究的后续行动，这是一项1994年开始的纵向研究，旨在描述MT期间发生的生理和心理社会变化，一直到老年早期（66-75岁）。它将扩大数据收集，将中年健康特征和可改变的风险因素与早期和快速认知能力下降、轻度认知障碍的发生率、心脏健康和老年早期的身体功能联系起来。SWAN-Aging将利用现有的SWAN科学专业知识和组织结构来创建三个综合项目。项目1将评估MT特征和中年健康指标对认知功能保护的影响（避免认知能力下降和轻度认知障碍的发生）、睡眠、泌尿生殖和性功能以及老年早期的生活质量;项目2将测试MT与心脏健康和心血管疾病（CVD）的关系老年早期女性的事件，并测试心脏健康与生命关键时期身体损伤、阿尔茨海默病和血管性痴呆的早期标志物的关系;项目3将研究MT和中年特征对肌肉骨骼健康和身体功能的作用。管理核心（核心1）的具体目标是：1）为SWAN老龄化提供领导、战略规划和组织基础设施; 2）促进研究者互动、创造力和生产力; 3）传播SWAN和SWAN老龄化结果并加强翻译; 4）确保SWAN数据的广泛使用并支持职业发展; 5）监测和保护参与者安全。核心1将协调和支持项目和核心的研究工作，并将提供执行研究操作所需的资源。核心1将支持一个综合科学委员会，该委员会将促进对认知，心脏和身体功能之间的相互关系及其对日常生活残疾活动的联合影响进行跨领域调查。核心1还将领导一个新的翻译和传播委员会，妇女健康专家将在该委员会中制定方法，向临床和非专业社区传播侧重于增进身体健康和预防痴呆症和残疾的严谨研究成果。行政核心将提供天鹅老龄化项目所需的结构，以成功地进行研究，产生有意义的研究结果，并转化临床相关的发现，以促进中年预防目标的识别，以延迟或避免轻度认知障碍，保持功能，保持独立性，并优化老年早期的生活质量。

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, Alzheimer’s disease, Alzheimer’s disease related dementia, physical disability and multi-morbidity in old age. This U19 proposal will extend follow-up of the Study of Women’s Health Across the Nation (SWAN), a longitudinal study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT, into early old age (66-75 years). It will expand data collection to link midlife health characteristics and modifiable risk factors to early and rapid cognitive decline, incidence of mild cognitive impairment, cardiac health, and physical function in early old age. SWAN-Aging will leverage the existing SWAN scientific expertise and organizational structure to create three integrated Projects. Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of the MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Administrative Core (Core 1) are to: 1) Provide leadership, strategic planning, and organizational infrastructure for SWAN-Aging; 2) Facilitate investigator interaction, creativity, and productivity; 3) Disseminate SWAN and SWAN-Aging results and enhance translation; 4) Ensure broad use of SWAN data and support career development; and 5) Monitor and protect participant safety. Core 1 will coordinate and support research efforts across the Projects and Cores and will supply the required resources to execute study operations. Core 1 will support an Integrative Sciences Committee that will facilitate cross-cutting investigations of the interrelationships between cognitive, cardiac, and physical function, and their joint impact on activities of daily living disability. Core 1 will also lead a new Translation and Dissemination Committee in which experts in women’s health will develop methods for disseminating rigorous research results focused on the enhancement of physical health and the prevention of dementia and disability for clinical and lay communities. The Administrative Core will provide the structure required for the SWAN-Aging Projects to successfully conduct their studies, produce meaningful research results, and translate clinically relevant findings to facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.