Administrative Core

行政核心项目摘要 我们蓬勃发展的天然产物药物相互作用研究卓越中心（NaPDI中心）已经实现了 在建立严格和明确的方法，设计和自然的行为， 产品（NP）-药物相互作用（NPDI）研究和推进我们对药代动力学NPDI的理解 由四种精心挑选的高优先级NP沉淀：绿色茶、白毛茛、大麻和克拉通。的 NAPDI中心的成功反映了多种机构间和机构内合作的有效性 在行政核心提供的后勤、财政和智力支持下，有效和高效地开展工作。角色 行政核心的职责和责任被纳入NaPDI中心的所有活动， 在方案和项目层面，确保达到规定的项目里程碑并在预算范围内。 行政核心的成就来自于精简的领导结构和定期、有效的 中心研究者之间的沟通。如本续期申请书所述，我们提出三项具体建议， AIMS是现有核心功能的延续，具有多种创新。目标1：行政 核心将协调组成三个科学核心（药理学， 分析和信息学）及其相关学术机构，确保最大的科学生产力 财政凝聚力。行政核心将与全国儿童健康协调委员会合作，建立一个指导委员会， 监督NaPDI中心计划，2）监控互动项目的进展和数据的扩展 知识库和公共门户网站，以及3）在必要时建议科学方向的变化。此外该 行政核心将确保中心研究者与外部顾问之间的有效沟通 定期提供项目进展的最新情况，并利用专家小组在相关领域的丰富专门知识， 学科，以告知中心的战略方向，并帮助解决具体的项目挑战。目标2： 行政核心将与信息学核心合作，制定和实施创新指标，以评估 计划成功，年度里程碑的完成，以及特定项目成果对科学领域的影响 以及公众健康和安全。目标3：行政核心将领导广泛传播 最佳做法方法和建议的方法， 人体机制的体外和临床NPDI研究。这些活动将包括采取创新办法， 扩大与国家和国际科学界的联系。我们久经考验的行政团队 制定了一个高效的运营模式，以确保中心的持续生产力， 翻译中心生成的数据，以改善公共卫生。

PROJECT SUMMARY OF THE ADMINISTRATIVE CORE Our thriving Center of Excellence for Natural Product Drug Interaction Research (NaPDI Center) has achieved tremendous success in establishing rigorous and definitive approaches for the design and conduct of natural product (NP)-drug interaction (NPDI) studies and advancing our understanding of pharmacokinetic NPDIs precipitated by four carefully selected high priority NPs: green tea, goldenseal, cannabis, and kratom. The success of the NaPDI Center reflects multiple inter-institutional and intra-institutional collaborations that worked effectively and efficiently with logistical, fiscal, and intellectual support provided by the Administrative Core. Roles and responsibilities of the Administrative Core are integrated into all NaPDI Center activities, at both the programmatic and project levels, ensuring that prescribed project milestones are met and within budget. Accomplishments of the Administrative Core derive from a lean leadership structure and regular, effective communication between Center investigators. As detailed in this renewal application, we propose three SPECIFIC AIMS that represent a continuation of existing Core functions with multiple innovations. AIM 1: the Administrative Core will coordinate project activities of the investigators composing the three scientific Cores (Pharmacology, Analytical, and Informatics) and their associated academic institutions, ensuring maximal scientific productivity and fiscal cohesion. The Administrative Core will partner with NCCIH to establish a Steering Committee that 1) oversees the NaPDI Center program, 2) monitors progress of the Interaction Projects and expansion of the data repository and public portal, and 3) recommends changes in scientific direction when warranted. In addition, the Administrative Core will ensure effective communication between Center investigators and the External Advisory Panel by providing regular updates of project progress and tapping the Panel’s wealth of expertise in relevant disciplines to inform strategic directions of the Center and help address specific project challenges. AIM 2: the Administrative Core will work with the Informatics Core to develop and implement innovative metrics to evaluate program success, completion of annual milestones, and impact of specific project outcomes on the scientific field and public health and safety. AIM 3: the Administrative Core will provide leadership for the broad dissemination of best practice methodologies and recommended approaches developed by the Center for the optimal conduct of human mechanistic in vitro and clinical NPDI studies. These activities will include innovative approaches to broaden outreach to national and international scientific communities. Our time-tested administrative team has developed a highly effective operational paradigm that will ensure continued productivity of the Center and translation of Center-generated data to improve public health.