Accelerating nerve regeneration with botulinum toxin and electrical stimulation therapies

项目摘要 周围神经损伤是一个被低估的公共卫生问题。约有 美国每年新增20万例。绝大多数患者的恢复不完全 因为神经再生缓慢且效率低下。不幸的是， 改善神经再生过程的治疗方法。我们已经确定了两个 互补疗法，以便针对神经的（i）早期和（ii）晚期 再生过程它们都可以作为独立的治疗或潜在的 组合，正如我们预测的那样，它们将对神经修复有额外的好处。本 该提案将为后续临床试验奠定基础，以将最有希望的治疗方法带到 患者我们相信我们可以朝着这个目标取得快速进展，因为一种治疗方法 代表了一种已经FDA批准的药物的再利用，另一种疗法是一种形式， 电刺激已经在神经损伤的小型临床试验中显示出有效性。的 电刺激治疗需要一种新的输送模式，以消除临床治疗的障碍。 实现，我们提供了通过新的瞬态生物电植入系统。总的来说， 这项提案将为我们如何改善对患有 周围神经损伤，以最大限度地恢复功能。

Project Summary Peripheral nerve injuries are an under-appreciated public health problem. There are about 200,000 new cases per year in the USA. Recovery is incomplete for the vast majority of patients who suffer from one because nerve regrowth is slow and inefficient. Unfortunately, there are no approved treatments to improve the process of nerve regeneration. We have identified two complimentary therapies in order to target the (i) early and (ii) late phases of the nerve regeneration process. They each may work as stand-alone therapy or potentially in combination, as we predict they will have an additive benefit on nerve repair. The present proposal will set the stage for a follow up clinical trial to bring the most promising therapy to patients. We believe we can make rapid progress towards this goal because one therapy represents a repurposing of an already FDA-approved drug, and the other therapy is a form of electrical stimulation that already has shown efficacy in small clinical trials for nerve injury. The electrical stimulation therapy is in need of a new mode of delivery to remove barriers to clinical implementation, which we offer by means of novel transient bio-electric implant system. Overall, this proposal will deliver a new horizon in how we can improve the treatment of patients with peripheral nerve injuries to maximize their functional recovery.