Interdisciplinary Training Program in Muscle Biology

该项目为博士后和博士后学生提供肌肉生物学的跨学科培训。 伙计们。该计划强调骨骼、心脏和心脏的功能、结构和分子性质 平滑肌，以及这些特性在各种疾病状态下是如何受损的。我们的18名教职员工 来自2个基础科学系(生物化学、分子生物学和生理学)和5个临床 医学系(内科、骨科、病理学、物理治疗及康复、外科) 马里兰大学医学院。附属教职人员也来自机械系 在我们的姊妹校区，马里兰大学巴尔的摩县分校的工程和数学与统计专业，以及 来自摩根州立大学。学员来自所有参与的部门和我们的 跨部门博士项目。我们提供的培训表明了我们教师背景的多样性 从肌肉发育的分子决定因素到细胞生物学方面的多方面 肌肉细胞骨架、膜和基质，用于个体肌肉细胞功能的生物物理分析和 所有这些水平的整体肌肉对肌肉疾病影响的生物力学评价 调查。在肌肉的钙离子控制方面，我们的教师在国内和国际上都是公认的。 功能和膜系统，肌肉细胞骨架和细胞外基质，肌肉发育，生长 和可塑性，以及肌肉疾病、损伤和衰老。我们的学生将接受这些方面的培训以及 各种相关领域，重点是使用补充的最先进技术来解决 每一道题都在考题中。我们培训的主要教学方面是两个为期一学期的跨学科 关于肌肉生物学的课程，由项目教员团队教授，过去一直很受欢迎 学员，以及集中于肌肉相关技术、技术和模型系统的一系列研讨会。 计划活动包括年度校园小型务虚会，包括实习生海报和口头 演讲和著名的肌肉研究人员，作为项目访问者和主旨发言人，每半年举行一次Wade 为所有受训人员举办纪念讲座和午餐会，以及职业生涯发展培训， 赠款和手稿写作，严谨和可重复性的原则，以及负责任的研究行为。 在整个续订期间，我们将继续保持目前的5名博士前和5名博士后实习生的水平。 进入博士前实习生将被要求具有强大的生物科学背景和表扬 推荐信。即将到来的博士后实习生将完成扎实的博士论文，并拥有 强有力的推荐信。该项目的实习生将准备好将广泛的方法 致力于回答肌肉生物学中的基本问题和肌肉疾病的原因以及 他们可能的治疗方法并最终治愈。因此，这一计划服务于国家高度准备的需要 在肌肉生物学和疾病领域接受过多学科培训的称职调查人员。

This program provides interdisciplinary training in muscle biology for predoctoral students and postdoctoral fellows. The program emphasizes the functional, structural and molecular properties of skeletal, cardiac and smooth muscle, and how these properties are compromised in various disease states. Our 18 faculty members come from 2 basic science departments (Biochemistry & Molecular Biology and Physiology) and 5 clinical departments (Medicine, Orthopedics, Pathology, Physical Therapy & Rehabilitation, and Surgery) at the University of Maryland School of Medicine. Affiliate faculty also come from the Departments of Mechanical Engineering and Mathematics & Statistics at our sister campus, University of Maryland Baltimore County, and from Morgan State University. Trainees are drawn from all of the participating departments and from our interdepartmental PhD Programs. Indicative of the diversity of our faculty backgrounds, the training offered is multifaceted ranging from the molecular determinants of muscle development through the cell biological aspects of muscle cytoskeleton, membranes and matrix, to the biophysical analysis of individual muscle cell function and the biomechanical evaluation of whole muscles to the effects of muscle disease at all these levels of investigation. Our faculty is nationally and internationally recognized in the areas of Ca2+ control of muscle function and membrane systems, muscle cytoskeleton and extracellular matrix, muscle development, growth and plasticity, as well as muscle disease, injury and aging. Our students will receive training in these and in a variety of related areas, with emphasis on the use of complementary state-of-the-art technologies to address each question under examination. The major didactic aspect of our training is two one-semester interdisciplinary courses on muscle biology, which are team-taught by the program faculty and have been well received by past trainees, and a seminar series focusing on muscle related techniques, technologies and model systems. Program activities comprise an annual on campus Mini-Retreat which includes trainee poster and oral presentations and a renowned muscle researcher as Program visitor and Keynote Speaker, a semi-annual Wade Memorial lectureship and lunch meetings for all trainees, as well as training in professional career development, grant and manuscript writing, the principles of rigor and reproducibility, and the responsible conduct of research. We will continue at our present level of 5 predoctoral and 5 postdoctoral trainees throughout the renewal period. Entering predoctoral trainees will be required to have a strong background in biological sciences and praising recommendation letters. Incoming postdoctoral trainees will have completed a solid PhD thesis, and also have strong recommendation letters. Trainees from this program will be prepared to bring a wide range of approaches to bear on answering fundamental questions in muscle biology and on the causes of muscle diseases as well as their possible treatment and ultimately cure. This program therefore serves a national need for preparing highly competent investigators with multi-disciplinary training in the area of muscle biology and disease.