促炎刺激调节金属转运蛋白 ZIP14 的功能-猫眼课题宝

促炎刺激调节金属转运蛋白 ZIP14 的功能

批准号：

10474233

负责人：

ROBERT J COUSINS

金额：

$15.24万

依托单位：

UNIVERSITY OF FLORIDA

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-09-23 至 2023-08-31

来源：

https://reporter.nih.gov/project-details/10474233

关键词：

Ablation Acute-Phase Proteins Address Binding Binding Sites Biological Assay CCAAT-Enhancer-Binding Proteins Catalytic Domain Chelating Agents Computer software DNA Methylation Data Deacetylation Diet Dietary Zinc Effectiveness Enterocytes Enzymes Epigenetic Process Epithelial Cells Event Female GATA4 gene Gene Expression Genes Genetic Transcription Genomic DNA Genotype Goals HDAC1 gene HDAC3 gene Health Health Promotion Histone Acetylation Histone Deacetylase Histone Deacetylase Inhibitor Histones Human IL18 gene Immunity Individual Inflammation Intestinal permeability Intestines Leaky Gut Link Literature Measures Mediating Metals Methylation MicroRNAs Micronutrients Modification Mus NF-kappa B Nuclear Extract Nuclear Proteins Nuclear Receptors Permeability Pharmaceutical Preparations Production Proteins Reagent Reporting Research Reverse Transcriptase Polymerase Chain Reaction STAT3 gene Signal Pathway Site Skeletal Muscle Small Intestines Stimulus Structure Suggestion Testing Time Trichostatin A Zinc Zinc Fingers Zinc supplementation base chelation chromatin immunoprecipitation chromatin modification claudin-1 protein demethylation dietary differential expression drinking water experimental study genome browser histone acetyltransferase histone demethylase histone methylation histone modification in silico indexing inhibitor/antagonist interest intestinal barrier intestinal epithelium intestinal homeostasis microbial prevent promoter protein expression response systemic inflammatory response transcription factor

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中文摘要

翻译

此R56项目的摘要指导性假设：Zip14(Slc39a14)介导的锌转运影响肠细胞的基因表达，进而改变肠屏障功能。目的：评价肠道细胞特异性Zip14消融和补锌对表观遗传学改变的作用机制，包括组蛋白甲基化和乙酰化、转录因子激活以及调节肠上皮细胞影响屏障功能的基因的lncRNAs和miRNAs。

英文摘要

Abstract For This R56 Project Guiding Hypothesis: Zinc transport mediated by Zip14 (Slc39a14) influences gene expression in enterocytes that in turn alters intestinal barrier function. Goal: Evaluate mechanisms of enterocyte-specific Zip14 ablation and replacement zinc supplementation on epigenetic alterations including histone methylation and acetylation, transcription factor activation and lncRNAs and miRNAs that regulate genes in intestinal epithelial cells which influence barrier function.

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