Initiative to Maximize Research Education in Genomics: Diversity Action Plan (DAP)

项目摘要/摘要 美国(US)科学、技术、工程和数学(STEM)劳动力 几十年来一直是生物医学研究的世界领先者，在21世纪，美国在 对人类基因组进行测序。STEM劳动力也面临着不断增加的挑战 代表不足(UR)人群的参与，以保持在科学和工程领域的竞争力。这个 国家人类基因组研究所(NHGRI)从人类一开始就有先见之明 基因组计划将包括培训(多样性行动计划-DAP)，以解决这一短缺问题 油田开发。尽管进行了多次国家干预，但一些少数群体的代表性仍然偏低。 例如，在#年授予的76,447个博士学位中， 2012年，只有3677人(4.8%)是非洲裔美国人，4463人(5.8%)是西班牙裔， 314人(0.41%)是美洲原住民。因此，制定干预方案 寻求改善科学研究中的这些差距变得重要和必要。 这项提议的长期目标是增加基因组学和生物信息学方面的UR博士学位。我们会 在两个具体目标中实现这一目标。目标1将提供6名本科生和8名学士后 学生DI培训活动可使75%的学生以更高的成绩完成计划 基因组学/生物信息学知识和基于实验室的批判性思维技能 研究生院。尽管在生物医学研究中，UR博士的数量很少，但在 生物信息学在这一领域缺乏美国训练有素的科学家，而UR小组更是如此 在这一新领域受到严重限制。AIM 2计划招聘并保留50%的直接投资实习生作为研究生 在贝勒医学院分子和人类遗传学系。非裔美国人 在所有向MHG部门申请的人数不足的群体中，申请者人数最少。我们会 在HGSC-DI夏季研究中，以研究性培训为基础，解决这些目标 实习和毕业后课程。我们的程序数据显示以下DI结果：72% 我们的学士学位后学生进入博士项目；100%的博士前校友保留在 博士课程；100%的暑期实习生获得学士学位。我们有被证明的能力 在STEM招收和留住学生。这项提案的总体影响将增加UR的数量 获得基因组学博士学位，并接受生物信息学培训。

Project Summary/Abstract The United States (US) science, technology, engineering, and mathematics (STEM) workforce has been a world leader in biomedical research for decades, and in the 21st century the US took the lead in sequencing the human genome. The STEM workforce has also faced the challenge of increasing participation of under-represented (UR) populations to remain competitive in science and engineering. The National Human Genome Research Institute (NHGRI) had the foresight from the outset of the Human Genome Project to include training (Diversity Action Plan-DAP) that would address this shortage as the field developed. In spite of many national interventions, several minority groups remain underrepresented at all degree and professional career levels.1-2 For example, of the 76,447 doctorate degrees awarded in the biological sciences in 2012, only 3,677 (4.8%) were African Americans, 4,463 (5.8%) were Hispanics, and 314 (0.41%) were Native Americans. 1 Therefore, the development of intervention programs seeking to ameliorate these disparities within science research become important and necessary. The long term goal of this proposal is to increase UR PhDs in genomics and bioinformatics. We will approach this goal in two specific aims. Aim 1 will provide six undergraduate and 8 post-baccalaureate students DI training activities that result in 75% completing the program with greater genomics/bioinformatics knowledge and lab-based critical thinking skills appropriate for success in graduate school. Although the number of UR PhDs is low in biomedical research, in the field of bioinformatics there is a shortage of US trained scientists in this area and the UR groups are even more severely limited in this new field. Aim 2 plans to recruit and retain 50% of DI trainees as graduate students in the Molecular and Human Genetics Department at Baylor College of Medicine. The African American applicant pool is lowest among all under-represented groups that apply to the MHG department. We will address these aims, using research training as our foundation, in the HGSC-DI summer research internship and Post-baccalaureate programs. Our program data indicates the following DI results: 72% of our post-baccalaureate students enter PhD programs; 100% of pre-doctoral alumni are retained in PhD programs; and 100% of the summer interns obtain bachelor's degrees. We have proven ability to recruit and retain students in STEM. The overall impact of this proposal will increase the number of UR PhDs in genomics and trained in bioinformatics.