Integrated Genomics of Mucosal Infections

粘膜感染的综合基因组学

基本信息

  • 批准号:
    10446469
  • 负责人:
  • 金额:
    $ 50万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-17 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

Overall Project Summary This application requests funding for a Genomics Center for Infectious Disease (GCID) in the Texas Medical Center (TMC) that comprises a multidisciplinary, integrated team of basic and physician scientists at Baylor College of Medicine, the University of Texas-Houston School of Public Health, and MD Anderson Cancer Center. The overall goal of our GCID is to: i) leverage our decades of experience in genomic sequencing technology with our renowned clinical expertise, and the use of novel ex vivo organotypic models of human intestinal and pulmonary function, to create a platform for large scale genomics-based interrogation of host-mucosal pathogen interactions in the context of human tissues, and ii) utilize this platform for the discovery of novel therapeutic and diagnostic targets based on host and microbial genomic and transcriptomic profiles. Project 1 (PL: A. Maresso, PhD) will dissect the genomic elements that confer the ability of pathogenic members of the Enterobacteriaceae and Enterococcaceae to associate with the human intestinal mucosa while also determining the host response to this association. Project 2 (PL: M. Estes, PhD) will leverage integrated analyses of human norovirus and respiratory syncytial virus full-length genomic sequences and characterization of the ecological niche of samples from clinically relevant patient sub-groups for new understanding of viral replication, recombination and evolution, induction of disease and host factors required for susceptibility to infection and pathogenesis. Project 3 (PL: D. Corry, MD) will test the hypothesis that fungal diversity, virulence, and individual innate immune responses to fungal burdens underlie persistent, treatment-resistant moderate to severe asthma in a new paradigm whereby fungal burden within the respiratory tract (“airway mycosis”) may have a causative role in development and persistence of allergic lung inflammation. Project 4 (PL: P. Okhuysen, MD) will build on a novel Cryptosporidium discovery made by the project leaders and test the hypothesis that one or more indole-producing commensal microbes in the gut can prevent or eliminate Cryptosporidium infection. All four research projects will utilize human intestinal and lung organoid cultures along with niche-specific, defined microbial communities supplied by the Organoid and Minibioreactor Array Cultivation Core and a large collection of unique clinical samples and isolates, incorporating cutting edge, high-throughput sequencing strategies and technologies supplied by the Sequencing Technology (ST) Core. Paradigm-shifting discoveries, data, tools, and reagents will be disseminated to the infectious disease community by the Data Management Analysis and Resource Dissemination (DMARD) Core through a state of the art portal developed by DNAnexus. The result will be a comprehensive genetic profiling of hosts and microbes in human infection models that will reveal pathogen genetic variants, and individual host response phenotypes to inform precision medicine-based therapeutics and diagnostics, both for the pathogens in this proposal and a broad spectrum of mucosal infectious diseases that severely impact human health.
整体项目总结 此应用程序请求为德克萨斯医疗中心的传染病基因组学中心(GCID)提供资金 该中心(TMC)由贝勒的基础和内科科学家组成的多学科综合团队组成 医学院、德克萨斯大学-休斯顿公共卫生学院和MD安德森癌症中心。 我们GCID的总体目标是:i)利用我们几十年来在基因组测序方面的经验 技术与我们著名的临床专业知识,并使用新的体外器官模型 人体肠道和肺功能,打造以大规模基因组学为基础的平台 在人类组织的背景下询问宿主-粘膜病原体的相互作用,以及ii)利用这一点 基于宿主和微生物的发现新的治疗和诊断靶点的平台 基因组和转录组图谱。项目1(PL:A.Maresso,PhD)将剖析 赋予肠杆菌科和肠球菌科的致病成员与 同时也确定了宿主对这种联系的反应。项目2(PL:M.Estes, PHD)将利用对人类诺如病毒和呼吸道合胞病毒全长基因组的综合分析 临床相关患者亚群样本的生态位序列和特征 对病毒复制、重组和进化、疾病诱发和宿主因素的新认识 感染易感性和致病机制所必需的。项目3(PL:D.Corry,MD)将测试假设 真菌多样性、致病力和个体对真菌负担的先天免疫反应是持久的、 治疗难治性中重度哮喘--呼吸道真菌负荷的新范例 呼吸道真菌病(“呼吸道真菌病”)可能在过敏性肺部炎症的发展和持续中起到致病作用。 项目4(PL:P.Okhuysen,MD)将建立在项目负责人发现的新隐孢子虫的基础上 并测试一种假设,即肠道中一种或多种产生吲哚的共生微生物可以防止或 消除隐孢子虫感染。所有四个研究项目都将利用人体肠道和肺的有机物质 培养以及由有机物和微型生物反应器提供的特定于生态位的微生物群落 阵列培养核心和大量独特的临床样本和分离株,结合了尖端技术, 由测序技术(ST)核心提供的高通量测序策略和技术。 改变范式的发现、数据、工具和试剂将传播到传染病社区 由数据管理分析和资源传播(DMARD)核心通过最先进的门户 由DNANXUS开发。其结果将是对人类宿主和微生物的全面遗传图谱 感染模型将揭示病原体的遗传变异,并告知个别宿主的反应表型 基于精确医学的治疗和诊断,既针对本提案中的病原体,也针对广泛的 严重影响人类健康的一系列粘膜传染病。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

RICHARD A GIBBS其他文献

RICHARD A GIBBS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('RICHARD A GIBBS', 18)}}的其他基金

Frequency of variants of unknown significance by ancestry groups in the All of Us Research Program cohort
我们所有人研究计划队列中不同祖先群体的未知意义变异的频率
  • 批准号:
    10659798
  • 财政年份:
    2021
  • 资助金额:
    $ 50万
  • 项目类别:
Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)
贝勒医学院 - 孟德尔基因组研究中心 (BCM-MGRC)
  • 批准号:
    10653049
  • 财政年份:
    2021
  • 资助金额:
    $ 50万
  • 项目类别:
Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)
贝勒医学院 - 孟德尔基因组研究中心 (BCM-MGRC)
  • 批准号:
    10217746
  • 财政年份:
    2021
  • 资助金额:
    $ 50万
  • 项目类别:
Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)
贝勒医学院 - 孟德尔基因组研究中心 (BCM-MGRC)
  • 批准号:
    10451734
  • 财政年份:
    2021
  • 资助金额:
    $ 50万
  • 项目类别:
GENOMIC APPROACHES TO UNDERSTAND DISEASE SUSCEPTIBILITY AND PATHOGENESIS OF SARS-COV-2
了解 SARS-COV-2 疾病易感性和发病机制的基因组学方法
  • 批准号:
    10172492
  • 财政年份:
    2020
  • 资助金额:
    $ 50万
  • 项目类别:
Integrated Genomics of Mucosal Infections
粘膜感染的综合基因组学
  • 批准号:
    10160776
  • 财政年份:
    2019
  • 资助金额:
    $ 50万
  • 项目类别:
Initiative to Maximize Research Education in Genomics: Diversity Action Plan (DAP)
最大化基因组学研究教育的倡议:多样性行动计划(DAP)
  • 批准号:
    10205135
  • 财政年份:
    2019
  • 资助金额:
    $ 50万
  • 项目类别:
Initiative to Maximize Research Education in Genomics: Diversity Action Plan (DAP)
最大化基因组学研究教育的倡议:多样性行动计划(DAP)
  • 批准号:
    9793733
  • 财政年份:
    2019
  • 资助金额:
    $ 50万
  • 项目类别:
Initiative to Maximize Research Education in Genomics: Diversity Action Plan (DAP)
最大化基因组学研究教育的倡议:多样性行动计划(DAP)
  • 批准号:
    10631939
  • 财政年份:
    2019
  • 资助金额:
    $ 50万
  • 项目类别:
Integrated Genomics of Mucosal Infections
粘膜感染的综合基因组学
  • 批准号:
    10601123
  • 财政年份:
    2019
  • 资助金额:
    $ 50万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 50万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了