A tailored, health communication intervention for HPV vaccine hesitant families

摘要 人类乳头瘤病毒(HPV)导致90%的宫颈癌，并与多种其他癌症有关。 HPV疫苗可以预防这些癌症中的绝大多数，但在青少年中使用不足，特别是 在那些疫苗犹豫不决(VH)父母中。埃尔维斯博士，梅哈里大学研究助理教授 范德比尔特大学医学院兼职助理教授，即将成为 行为癌症预防研究。这项指导研究科学家发展奖(K01)将 补充她在公共卫生研究方法、统计分析、以患者为中心方面的深入培训 在她的博士、博士后和早期职业生涯中获得的成果研究和社区参与 经历。它将为她提供所需的培训，以进一步推进她目前的癌症预防研究计划， 非裔美国青少年和父母在做出决定时的偏好和感知需求 关于接种HPV疫苗预防癌症。埃尔维斯博士的短期目标是精通行为学 干预开发，进行临床试验的专家，对实施科学了如指掌 通过从事教学、临床研究培训活动；进行试点、随机临床试验； 在该奖项的第三年提交R01；增加手稿出版物；促进领导力 通过科学演示。她的导师包括高素质的社区参与专家和 临床试验(Consuelo Wilkins博士)、HPV疫苗接种和行为干预(Pamela Hull博士)，以及 疫苗犹豫不决、临床干预和实施科学(阿曼达·邓普西博士)最先进的 梅哈里医学院和范德比尔特大学的设施和丰富的资源提供了环境 需要促进她的职业发展，并成功完成拟议的研究。建议数 研究是开发和试点一种量身定做的健康沟通干预措施，旨在增加HPV 在VH父母中接种疫苗。这项研究将增加关于如何在教育之前提供定制教育的知识 医生的拜访可以在提高服务不足的VH父母中的HPV疫苗接种率方面发挥作用。这项研究 旨在为HPV VH父母制定量身定制的健康沟通干预措施(目标1)；进行试点 小规模干预和研究方案的研究，以论证未来全面实施的可行性 随机对照试验(RCT)(AIM 2)；并检查方案的可接受性和干预 家长和提供者(目标3)。这项拟议的研究是创新的，因为没有基于证据的健康 沟通干预针对HPV VH父母，我们将在整个过程中使用利益相关者参与 学习。该奖项提供的知识、经验和试点数据将使埃尔维斯博士做好准备，以确保 随后的R01资助，以评估干预的效果，在一个强大的随机对照试验中，并推动HER 关于提高HPV疫苗接种率的行为干预的多学科研究计划。这一奖项将 允许她建立一个独立的、长期的职业生涯，更广泛地专注于癌症预防行为。

Abstract The human papillomavirus (HPV) causes 90% of cervical cancers and is implicated in multiple other cancers. The HPV vaccine can prevent the vast majority of these cancers, but it is underused in adolescents, especially among those within vaccine hesitant (VH) parents. Dr. Erves, an Assistant Professor in Research at Meharry Medical College and Adjunct Assistant Professor at Vanderbilt University, is poised to become a leader in behavioral cancer prevention research. This Mentored Research Scientist Development Award (K01) will complement her in-depth training in public health research methods, statistical analysis, patient centered outcomes research, and community engagement obtained during her doctoral, post-doctoral, and early career experiences. It will provide the training she needs to further her current cancer prevention research program, characterizing preferences and perceived needs of African American adolescents and parents when deciding about HPV vaccination for cancer prevention. Dr. Erves short-term goals are to become proficient in behavioral intervention development, an expert in conducting clinical trials, and knowledgeable of implementation science by engaging in didactic, clinical research training activities; conducting a pilot, randomized clinical trial; submitting an R01 in Year 3 of this award; increasing manuscript publications; and advancing leadership through scientific presentations. Her mentors include highly-qualified experts in community engagement and clinical trials (Dr. Consuelo Wilkins), HPV vaccination and behavioral interventions (Dr. Pamela Hull), and vaccine hesitancy, clinical interventions, and implementation science (Dr. Amanda Dempsey). State-of-the-art facilities and vast resources at Meharry Medical College and Vanderbilt University provide the environment needed to promote her career development, and complete the proposed research successfully. The proposed research is to develop and pilot test a tailored, health communication intervention aimed to increase HPV vaccination among VH parents. The research will add knowledge on how tailored education provided before a doctor’s visit can play a role in improving HPV vaccination rates among underserved, VH parents. The study aims to develop a tailored, health communication intervention for HPV VH parents (AIM 1); conduct a pilot study of the intervention and study protocol on a small scale to demonstrate feasibility of a future full-scale randomized control trial (RCT) (AIM 2); and examine acceptability of the protocol and intervention among parents and providers (AIM 3). The proposed research is innovative because no evidence-based health communication interventions target HPV VH parents, and we will use stakeholder engagement throughout this study. The knowledge, experience, and pilot data provided by this award will prepare Dr. Erves to secure subsequent R01 funding to assess the intervention’s efficacy in a well-powered RCT and advance her multidisciplinary, research program on behavioral interventions to increase HPV vaccine rates. This award will allow her to establish an independent, long-term career focused more broadly on cancer prevention behaviors.