Molecular Analysis and Statistical Support Facility Core (MASS)

摘要 分子分析和统计支持（MASS）核心支持生物医学中心的主题， 环境健康和易感性（CEHS），翻译环境跨学科研究 北卡罗来纳州改善公共卫生健康敏感性。MASS将提供全面的， 用户友好，有效支持实验室，临床， 和基于人口的环境健康调查。MASS将提供访问和便利 利用一系列的分子核心，并将这种支持与严格的和最先进的 在研究设计、数据采集和数据分析方面提供生物统计学和生物信息学协助， 环境癌症，心脏病和发育领域的转化研究 疾病（目标1）。MASS将开发和实施新的分子和统计方法，以满足 研究人员的分析需求，并适应新兴的数据分析策略和独特的数据问题（目的 2）。MASS将提供技术培训，从分子方法到统计，生物信息学， 数据科学，通过研讨会，讲习班和专题讨论会为初级研究人员量身定制CEHS的需求 研究人员（目标3）。我们与整个校园在基因组学，暴露科学，数据科学和 计算医学，以扩大CEHS研究人员和初级研究人员的影响力和专业知识。 最后，MASS子核心与综合健康科学设施核心（IHSFC）协同运作。 支持现有的研究，新的试点项目，社区参与和赠款申请（目标4）。主要 在过去的赠款周期中，项目的努力和成就包括：更新基础设施， 仪器，使CEHS研究人员能够获得最先进的分析和分子技术; 一个新的方法开发奖励计划，以支持开发创新的新的曝光科学， CEHS研究人员的分子方法;以及CEHS最先进的新型数据分析管道 成员具有分子和定量方法开发专业知识的教师可作为 试点项目和外部赠款的合作者。我们的MASS设施核心提供了一个可扩展的，高质量的，全面的 服务核心设施，以满足我们的成员的数据采集和分析需求，从成立到 实施.

ABSTRACT The Molecular Analysis and Statistical Support (MASS) core supports the theme of the UNC Center for Environmental Health and Susceptibility (CEHS), translating interdisciplinary research on environmental health susceptibility to improve public health in North Carolina. The MASS will provide comprehensive, user-friendly, and efficient support for data acquisition, analysis, and interpretation needs of laboratory, clinical, and population-based investigations in environmental health. The MASS will provide access and facilitate utilization of a range of molecular cores and will integrate this support with rigorous and state-of-the-art biostatistics and bioinformatics assistance in study design, data acquisition, and data analysis to support translational research in the areas of Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease (Aim 1). The MASS will develop and implement new molecular and statistical methods to meet investigators' analytic needs and to adapt to emerging data analysis strategies and unique data problems (Aim 2). The MASS will provide technical training, ranging from molecular methods to statistical, bioinformatics, and data science, for junior investigators through seminars, workshops, and symposia tailored to the needs of CEHS researchers (Aim 3). We collaborate with campus-wide efforts in genomics, exposure science, data science and computational medicine to expand the influence and expertise of CEHS investigators and junior investigators. Finally, the MASS subcores function collaboratively with the Integrated Health Sciences Facility Core (IHSFC) to support existing research, novel pilot projects, community engagement, and grant applications (Aim 4). Major program efforts and accomplishments during the past grant cycle include: updated infrastructure and instrumentation to enable CEHS investigators to access state-of-the-art analytical and molecular technologies; a new Method Development Award Program to support developing innovative new exposure science and molecular methods for CEHS investigators; and novel state-of-the-art data analysis pipelines for CEHS members. Faculty with expertise in molecular and quantitative methods development are available and serve as collaborators on pilot projects and external grants. Our MASS facility core provides a scalable, high quality, full service core facility to address data acquisition and analytic needs of our membership, from inception to implementation.