Research Program: Cancer Basic Biology

项目摘要：癌症基础生物学(CBB) 癌症基础生物学(CBB)是癌症联盟中唯一的基础科学计划。它的使命是 三：开展与癌症有关的基础生物学研究；支持和开展转化性研究 这将为临床前和临床研究带来基础研究成果；并培训和指导下一代 一代癌症研究人员。从科学上讲，CBB研究有三个具体目标：(1)阐明 推动正常和癌细胞生物学的基本机制；(2)使用先进基因组学和 利用表观基因组学技术了解正常细胞和癌细胞的基因表达和表型； 开发和应用促进基础科学和癌细胞分析的新工具。每个目标都有一个 基础(发现)和翻译(临床前)组成部分。CBB计划领导层代表了这三个项目 学术机构和癌症基础研究的广度。项目联合负责人乔纳森 库珀和雷·莫纳特分别负责细胞生物学和基因组学/表观基因组学。联想 项目负责人David MacPherson和Barry Gumbiner在动物模型和细胞/结构方面增加了力量 生物学。CBB的四位领导人一致致力于促进对正常和正常动物基础生物学的研究 并促进新工具的开发和应用，以改进癌症诊断和治疗 心理治疗。该计划通过对肺癌、脑和其他癌症类型的研究使集水区受益 在我们地区造成严重的死亡率和发病率。我们的计划结构和领导层致力于促进 在CBB和整个研究项目中提供高质量的尖端科学，通过提供满足、 分享想法，开发新的协作机会。我们积极招募癌症患者的新成员- 具体的专业知识，并确定促进合作科学和翻译科学的新方法。CBB 成员在培训下一代癌症科学家方面发挥着额外的关键作用。 CBB项目目前有105名成员，其中38名在弗雷德·哈奇，63名在加州大学 自上一个周期以来，CBB已经净增加了32名成员。 CBB成员目前的研究支持为4320万美元(直接成本)，其中2730万美元为同行评议 资金，包括来自NCI的900万美元。CBB计划成员在一年中共发表了1057篇论文 当前赠款期间，其中12%是方案内方案，16%是方案间方案，48%是方案间方案 外部合著者。在12个财团共享资源中，有11个由CBB成员在 他们的工作进程。这笔P30赠款通过为以下项目提供行政和后勤支持来协助该计划 CBB会议，新研究项目的试点资金，以及新教师的招聘资源。

PROJECT SUMMARY: CANCER BASIC BIOLOGY (CBB) Cancer Basic Biology (CBB) is the sole fundamental science program in the Cancer Consortium. Its mission is three-fold: to conduct basic biological research related to cancer; to enable and conduct translational research that brings basic research findings to preclinical and clinical studies; and to train and mentor the next generation of cancer researchers. Scientifically, CBB research has three Specific Aims: (1) to elucidate the fundamental mechanisms that drive normal and cancer cell biology; (2) to use advanced genomics and epigenomics technologies to understand gene expression and phenotype in normal and cancer cells; and (3) to develop and apply new tools to facilitate basic science and cancer cell analyses. Each of these aims has a basic (discovery) and a translational (preclinical) component. The CBB Program leadership represents all three academic institutions and the breadth of fundamental research on cancer. Program Co-Leaders Jonathan Cooper and Ray Monnat take responsibility for cell biology and genomics/epigenomics, respectively. Associate Program Leaders David MacPherson and Barry Gumbiner add strength in animal models and cell/structural biology. All four CBB leaders are united in the goals of fostering research on the basic biology of normal and cancer cells and in promoting the development and application of new tools to improve cancer diagnosis and therapy. The program benefits the catchment area through research on lung, brain, and other cancer types that cause significant mortality and morbidity in our area. Our program structure and leadership work to foster high quality, cutting edge science within CBB and across Research Programs by providing opportunities to meet, share ideas, and develop new collaborative opportunities. We actively recruit new members with cancer- specific expertise, and identify new ways to promote both collaborative and translational science. CBB members play an additional key role in training the next generation of cancer scientists. The CBB Program currently has 105 members with 38 based at Fred Hutch, 63 based at University of Washington, and 4 based at Seattle Children’s. Since the prior cycle, CBB has gained a net of 32 members. The current research support of CBB members is $43.2M (direct costs), of which $27.3M is peer-reviewed funding, including $9M from the NCI. CBB Program members published a total of 1,057 papers over the current grant period, of which 12% were intra-programmatic, 16% were inter-programmatic, and 48% had external co-authors. Eleven of the 12 Consortium Shared Resources were utilized by CBB members in the course of their work. This P30 grant assists this program by providing administrative and logistical support for CBB meetings, pilot funding for new research projects, and recruitment resources for new faculty.