Effects of per- and polyfluoroalkyl substances on placental features and size at birth

项目总结 全氟和多氟烷基物质(PFAS)是普遍存在的高度持久的化学品，已经 在工业中广泛使用了70年，众所周知会对孕产妇和儿童健康产生不利影响。 最近，PFAS已成为公共卫生的优先事项，拜登总统呼吁采取行动防止 全氟辛烷磺酸的不利影响存在于我们的空气、水和食物供应中。实现这一目标需要 监测广泛的全氟辛烷磺酸并确定暴露于以下物质的现实情景对健康的影响 全氟辛烷磺酸混合物，尽管大多数先前的研究都是一次一个地调查全氟辛烷磺酸。此外，还需要数据 为国家政策提供信息，临床指南只能通过研究最易受影响的人来确定 人口，即孕妇和新生儿。因此，要告知国家政策和临床 指南中，我们建议调查与产前接触全氟辛烷磺酸相关的风险。 汉普郡出生队列研究，这是一个由2400多名母婴组成的大型美国农村队列，预计 招生人数为3000人。我们将调查怀孕期间在母亲血液中测量的全氟辛烷磺酸对 胎盘特征和出生大小，这是胎儿发育不足和过大的前哨结局 对婴儿发病率和死亡率以及心血管和代谢发病率的长期风险有很大影响 进入成年期。我们将利用我们长达十年的队列中现有的大量数据，包括有毒物质 暴露和临床元数据。我们将检验这一假设，即全氟辛烷磺酸单独或作为混合物会对 胎盘的特征和减少出生时的尺寸。此外，我们将探讨全氟辛烷磺酸与规模之间的关系。 分娩是通过PFAS对胎盘的影响来调节的。我们的工作将整合统计学方面的进展 评估暴露混合物和评估有效的联邦法规所适用的全氟辛烷磺酸的方法 还不存在。

PROJECT SUMMARY Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and highly persistent chemicals, that have been used widely in industry for seven decades and are known to adversely influence maternal and child health. PFAS have recently become a public health priority evidenced by President Biden’s call to action to prevent the adverse impacts from PFAS present in our air, water, and food supply. Achieving this goal necessitates monitoring a broad range of PFAS and determining the health effects of realistic scenarios of exposures to PFAS mixtures, though most prior research has investigated PFAS one at a time. Moreover, data are needed to inform national policies, and clinical guidelines can only be determined by studying the most susceptible populations, namely pregnant women and newborns. Therefore, to inform national policies and clinical guidelines, we propose to investigate the risks associated with prenatal exposure to PFAS in the New Hampshire Birth Cohort Study, a large rural U.S. cohort of over 2,400 mother-infant dyads with anticipated enrollment of 3,000. We will investigate the effects of PFAS, measured in maternal blood during pregnancy, on placental features and birth size, which is a sentinel outcome, with both insufficient and excessive fetal growth contributing to infant morbidity and mortality and enduring risk of cardiovascular and metabolic morbidity well into adulthood. We will leverage extensive extant data from our decade-long cohort, including toxicant exposure and clinical metadata. We will test the hypothesis that PFAS, alone and as mixtures, adversely affect placental features and reduce size at birth. Further, we will explore whether associations of PFAS with size at birth are mediated by the influence of PFAS on the placenta. Our work will integrate advances in statistical methodologies for evaluating exposure mixtures and evaluate PFAS for which effective federal regulations do not yet exist.