Clinical Pediatric Research Training for the Fetal-Neonatal Brain

总结/摘要 这一申请的理由是填补目前这一新兴学科临床研究培训的空白 胎儿-新生儿神经学胎儿和新生儿大脑的快速发育，以及独特的遗传和 威胁这种发展的环境因素，使未成熟的大脑明显不同于成年人的大脑。 甚至更大的婴儿。然而，尽管人们越来越认识到在这一关键时期发生的事件对生命周期的影响， 在这一时期，胎儿和新生儿神经病学的临床和研究培训仍然明显不足。 该计划的目标是提供临床神经科学研究的多学科培训， 胎儿/新生儿环境的背景。学员将进入一个为期两到三年的计划与医学博士，DO， PhD或MD/PhD。胎儿新生儿脑临床研究培训计划的主要网站 是位于华盛顿，华盛顿特区的儿童国家卫生系统（CNHS）。培训将在 负责任地进行研究，在NICU获得高通量的“床边”临床数据， 使用复杂的神经诊断技术处理和分析数据。两名NIH资助的校长 具有互补临床和研究专业知识的研究人员将得到神经科学的支持 导师（神经学、神经放射学、神经遗传学）和来自新生儿的导师/主题专家 重症监护、新生儿心脏手术和临床研究方法。导师团队是 来自儿童国家和乔治华盛顿大学（GWU）。儿童的国家是好的 定位为领导这一计划，基于（i）其在转化和临床研究的优势，和导师 在调查的核心领域;（ii）其正式资助的研究合作（CNICA计划）与Inova 妇女和儿童医院，以及（iii）其胎儿和新生儿医学方案的实力。每个 受训者将在先进神经诊断技术方面发展特殊专长， 科学在健康科学临床（MSHS）在GWU或同等学历，并将设计和实施 由她/他的导师团队监督的研究项目。到毕业时，受训人员将提交他/她的 向至少一次国家研究会议提交数据，向外部同行评审提交一份或多份手稿 期刊，并有一个精心制定的计划，为赠款申请。该计划将准备学员与 技能和专业知识，以发展成为未来的领导者，努力减少和预防胎儿脑损伤 和新生儿。

SUMMARY/ABSTRACT The rationale for this application is to fill the current void in clinical research training for the emerging discipline of fetal-neonatal neurology. The rapid development of the fetal and newborn brain, and the unique genetic and environmental factors that threaten such development, make the immature brain distinctly different from that of even older infants. Yet, despite the growing recognition of the lifespan impact of events during this critical period, clinical and research training in neurology of the fetus and newborn remains remarkably inadequate. The objective of this program is to provide multidisciplinary training in clinical neuroscience research within the context of the fetal/neonatal environment. Trainees will enter a two to three year program with an MD, DO, PhD or MD/PhD. The primary site for the Clinical Research Training Program for the Fetal Neonatal Brain is the Children’s National Health System (CNHS) in Washington, D.C. Training will be provided in the responsible conduct of research, the acquisition of high-throughput ‘bedside’ clinical data in the NICU, and the processing and analysis of data using sophisticated neurodiagnostic techniques. Two NIH-funded Principal Investigators with complementary clinical and research expertise will be supported by neuroscience preceptors (neurology, neuroradiology, neurogenetics), and mentors/subject matter experts from neonatal intensive care, neonatal cardiac surgery, and clinical research methodology. The mentorship team is assembled from Children’s National and the George Washington University (GWU). Children’s National is well positioned to lead this program, based on (i) its strengths in translational and clinical research, and mentorship in the central areas of inquiry; (ii) its formal funded research collaboration (CNICA Program) with Inova Women’s and Children’s Hospitals, and (iii) the strength of its fetal and neonatal medicine programs. Each trainee will develop special expertise in an advanced neurodiagnostic technique, complete a Master’s of Science in Health Sciences Clinical (MSHS) at GWU or equivalent, and will design and implement a research project overseen by her/his mentorship team. By graduation, the trainee will have presented his/her data to at least one national research meeting, submitted one or more manuscripts to external peer-reviewed journals, and have a well-formulated plan for a grant application. The program will prepare trainees with the skills and expertise to develop into future leaders in the effort to reduce and prevent brain injury in the fetus and newborn infant.