Adipose Tissue Core

摘要/汇总-ATC 脂肪组织由多种细胞类型组成(如脂肪细胞、成纤维细胞、干细胞 细胞、白细胞)控制脂肪组织储存营养物质和调节 新陈代谢。肥胖会导致所有AT细胞类型的质和量的变化 取决于身体的位置、新陈代谢状态和性别。脂肪的基础作用 肥胖症的组织扩张要求研究人员能够接触到试剂、技术和 评估脂肪细胞大小、脂肪组织炎性张力、血统关系的方法 临床前小鼠模型和人类模型中细胞类型和代谢功能之间的关系 样本。脂肪组织的高脂肪含量及其对组织加工极限的挑战 严格的脂肪组织评估在研究中的广泛应用导致 肥胖症研究领域的许多空白。脂肪组织核心(ATC)的建立是为了 解决这些差距帮助了一系列研究人员将脂肪组织 在他们的概念模型和实验中进行评估。空管委员会的目标是：(1) 就严格的实验方法提供咨询和培训，以调查 脂肪细胞通过旁分泌和内分泌发育、功能并与其他类型的细胞相互作用。 机械装置。(2)提供获得严格要求的专门技术的途径 评价脂肪组织生物学。(3)为调查人员提供组织、细胞、数据库、 最先进的化验、组织学和其他设备，以及用于研究的动物模型 脂肪组织功能。(4)开发和实施有利于MNORC的新技术 对脂肪组织生物学感兴趣的研究人员。将为排队的调查人员提供服务 在脂肪组织生物学专家的监督下，这些目标将确保严格和 评估脂肪组织功能的最新方法的可重复性应用 老鼠和人类的样本。

Abstract/Summary - ATC Adipose tissue is composed of a wide range of cell types (e.g. adipocytes, fibroblasts, stem cells, leukocytes) that control the ability of adipose tissue to store nutrients and regulate metabolism. Obesity leads to qualitative and quantitative alterations in all AT cell types that depends on location in the body, metabolic state, and sex. The fundamental role of adipose tissue expansion in obesity requires investigators access to the reagents, techniques, and assays to evaluate adipocyte size, adipose tissue inflammatory tone, lineage relationships between cell types, and metabolic function in pre-clinical mouse models as well as human samples. The high lipid content of adipose tissue and the challenges in tissue processing limit the broad application of rigorous adipose tissue assessments in research studies leading to many gaps in the field of obesity research. The Adipose Tissue Core (ATC) was established to address these gaps has assisted a range of investigators incorporate adipose tissue assessments in their conceptual models and experiments. The aims of the ATC are (1) To provide consultation and training on rigorous experimental approaches to investigate how adipocytes develop, function, and interact with other cell types through paracrine and endocrine mechanisms. (2) To provide access to the specialized techniques required to rigorously evaluate adipose tissue biology. (3) To provide investigators with tissues, cells, databases, state-of-the-art assays, histological and other equipment, and animal models for the study of adipose tissue function. (4) To develop and implement new technologies beneficial to MNORC investigators interested in adipose tissue biology. Services will be offered to investigators in line with these aims with oversight from experts in adipose tissue biology to ensure rigorous and reproducible application of state of the art approaches to assess adipose tissue function in mouse and human samples.