Cognitive and Neurobiological Approaches to Plasticity (CNAP) Center Phase 2

项目总结：总体 此第二阶段Cobre应用程序的目标是继续开发一种独特的、国家认可的 可塑性认知和神经生物学方法专题研究中心(CNAP)。我们将在此基础上 第一阶段取得成功，进一步加强研究基础设施，并继续建立临界质量的 研究认知和神经可塑性的研究人员。我们将继续发展塑性主题重点 通过支持三个新的交叉主题领域的研究：学习的神经生物学 和记忆，神经调节和评估，以及高级计算建模。横切 主题架起了跨越动物模型和人类翻译研究以及跨学科的桥梁。十字架- 切割主题反映了研究核心的计划增强，将当前项目编织在一起，将 指导教师招聘和未来试点资助和替代项目资助选择的优先事项，并将 通知未来的项目开发计划。CNAP中心及其附属机构的进一步发展 这些计划将推动我们实现改善认知和神经功能的目标， 在人群和患有特定疾病或障碍的个人中。将推进国家行动方案中心的发展 通过实现四个具体目标：(1)促进CNAP项目和试点R01奖的成功 资助金领袖。在第二阶段，我们将支持三位新的研究项目负责人，他们有很强的潜力 过渡到R01级别的支持。此外，随着我们积极的试点赠款计划在第一阶段取得成功， 我们将继续在第二至第五年每年资助试点助学金，为毕业提供更多机会 初级调查人员获得R01级研究支持。(2)继续发展一批临界性科研人员 通过招募新的CNAP成员来实现认知/神经可塑性。我们将招聘三个新的终身教职轨道 与CNAP交叉主题相关的研究领域的教师。我们将进一步扩大CNAP 通过资助新的试点赠款和扩大研究核心来成为成员。(三)进一步加强研究 通过扩大三个多用户核心实验室设施，扩大基础设施。我们将扩大行为 神经科学核心、认知神经科学核心和神经信息学核心 促进使用现代神经科学和计算建模技术的能力。(4)至 加强科学交流，提高CNAP中心成员的科研能力 网络(SEN)。SEN将为CNAP研究人员提供额外的核心设施和培训，以 提高他们获得外部资金的能力。实现这些目标将进一步推动一个蓬勃发展的 主题研究中心，将增加对可塑性认知和神经机制的理解。 国家行动方案将通过个人调查员和伙伴关系赠款吸引外部资金，将促进 促进调查员发展的研究环境，将继续加强研究基础设施，以及 将提供一条在第三阶段结束前实现中心长期可持续性的途径。

PROJECT SUMMARY: OVERALL The goal of this Phase 2 COBRE application is to continue to develop a unique, nationally recognized, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). We will build on Phase 1 successes by further enhancing research infrastructure and continuing to build a critical mass of investigators studying cognitive and neural plasticity. We will continue to develop the plasticity thematic focus of the center by supporting research in three new cross-cutting thematic areas: The Neurobiology of Learning and Memory, Neuromodulation and Assessment, and Advanced Computational Modeling. The cross-cutting themes bridge across animal models and human translational research, and across disciplines. The cross- cutting themes reflect the planned enhancements of the research cores, knit together the current projects, will guide priorities for faculty recruitment and future pilot grant and replacement project grant selection, and will inform future program development initiatives. Further development of the CNAP center and its associated programs will propel us toward achieving our goal of improving cognitive and neural functioning in both healthy populations and in individuals with specific diseases or disorders. CNAP center development will be advanced through the achievement of four specific aims: (1) To promote R01 award success for CNAP project and pilot grant leaders. In Phase 2, we will support three new research project leaders who have strong potential to transition to R01-level support. In addition, following the success of our active pilot grant program in Phase 1, we will continue to fund pilot grants annually in Years 2-5, providing further opportunities for graduation of junior investigators to R01-level research support. (2) To continue to develop a critical mass of researchers in cognitive/neural plasticity through recruitment of new CNAP members. We will recruit three new tenure-track faculty in research areas relevant to the CNAP cross-cutting themes. We will further expand CNAP membership by funding new pilot grants and expanding the research cores. (3) To further improve research infrastructure by expanding three multi-user core laboratory facilities. We will expand the Behavioral Neuroscience Core, Cognitive Neuroscience Core, and Neuroinformatics Core by adding significant new capabilities to promote access to modern neuroscience and computational modeling techniques. (4) To enhance the research capabilities of CNAP center members through strengthening the Scientific Exchange Network (SEN). The SEN will provide CNAP researchers access to additional core facilities and training to increase their capability to secure extramural funding. Achieving these aims will further advance a thriving thematic research center that will increase the understanding of cognitive and neural mechanisms of plasticity. CNAP will attract extramural funding through individual investigator and partnership grants, will promote a rich research climate for fostering investigator development, will continue to enhance research infrastructure, and will provide a pathway to long-term center sustainability by the end of Phase 3.