Center for Cancer Control in Persistent Poverty Areas (C3P2)

总体摘要 在美国，受持续贫困(PP)影响的地区的癌症死亡率高于 贫困并没有持续几十年，特别是与肥胖相关的癌症，如乳腺癌、前列腺癌和结直肠癌 癌症。虽然原因可能是多方面的，但健康的社会决定因素(SDH)的作用不能 被忽视，包括生活环境的各个方面(例如，物质和社会)及其“下游” 对影响健康促进和增加癌症风险和死亡率的行为的影响。2021年，阿拉巴马州 在美国的贫困排行榜上排名第八。该州包括一些最贫困的市中心和农村地区 全国的社区，因此有相当数量的城市和农村人口普查区(CT) 被国家癌症研究所(NCI)确定为PP地区。阿拉巴马大学的总体目标是 伯明翰(UAB)持续贫困地区癌症控制中心(C3P2)是为了减轻 通过扩大研究和研究能力，扩大癌症和癌症在PP地区的差异 多层次干预措施的实施和评估，以改善整个癌症控制领域的癌症结果 从预防到生存的连续统一体。C3P2的目标将通过以下方式实现：1)建立和 支持两个跨学科、多层次、多领域的研究项目，以适应、实施和评估 从预防到生存以及试点的癌症控制连续过程中的多层次干预 通过发展核心的项目；2)建立协调的C3P2基础设施，以支持和 通过以下方式加强C3P2研究议程：a)提供全面的综合管理和全面的 评价，b)提供共同研究资源和措施，以促进项目整合和 协作(行政、研究和方法核心)；3)开发调查人员渠道 通过提供培训、支持和研究经验机会，在PP领域进行癌症控制研究 早期职业调查人员(职业提升核心)；4)建立学术-社区合作伙伴关系 成立社区咨询委员会并聘请社区教练支持创新 并在社区中进行重点研究，并进行监测和评估，以确保实现拟议的 目标。(管理核心)。我们的多学科团队，由成熟的和早期的职业调查人员组成，工作 在一个支持性环境中，有资源和承诺来应对PP领域的挑战，以 癌症预防和控制，处于有利地位，将在阿拉巴马州和 改善癌症预后。C3P2将成为改善其他癌症预防和控制的典范 阿拉巴马州和其他州的人民党地区。

OVERALL ABSTRACT Cancer mortality is higher in areas of the US affected by Persistent Poverty (PP) compared to areas in which poverty has not persisted for decades, especially for obesity-related cancers like breast, prostate, and colorectal cancer. While reasons may be multifaceted, the role of social determinants of health (SDH) cannot be overlooked, including aspects of the Living Environments (e.g., physical and social) and their “downstream” effects on behaviors that impact health promotion and increase cancer risk and mortality. In 2021, Alabama ranked 8th in the US for poverty. The state includes some of the most impoverished inner-city and rural communities in the nation, and thus a considerable number of both urban and rural Census Tracts (CTs) identified as PP areas by the National Cancer Institute (NCI). The overall goal of the University of Alabama at Birmingham (UAB) Center for Cancer Control in Persistent Poverty Areas (C3P2) is to reduce the burden of cancer and cancer disparities in PP areas by expanding research and research capacity through implementation and evaluation of multilevel interventions to improve cancer outcomes across the cancer control continuum from prevention to survivorship. The C3P2 goal will be achieved through: 1) Establishment and support of two transdisciplinary, multi-level, multi-domain research projects to adapt, implement, and evaluate multilevel interventions across the cancer control continuum from prevention to survivorship, as well as pilot projects through a Developmental Core; 2) Establishment of a coordinated C3P2 infrastructure to support and strengthen the C3P2 research agenda by: a) providing overall integrated management and comprehensive evaluation, b) providing common research resources and measures to promote project integration and collaboration (Administrative and Research and Methods Cores); 3) Development of a pipeline of investigators for cancer control research in PP areas by providing training, support, and research experience opportunity to early career investigators (Career Enhancement Core); 4) Academic-community partnership building with establishment of a Community Advisory Board and engagement of Community COaCHes to support innovative and salient research in the community, and monitoring and evaluation to ensure achievement of proposed goals. (Administrative Core). Our multi-disciplinary team of established and early career investigators, working in a supportive environment with the resources and commitment to address and challenges in PP areas to cancer prevention and control, are well positioned to make an impact in PP communities of Alabama and improve cancer outcomes. The C3P2 will serve as a model to improve cancer prevention and control for other PP areas in Alabama and other states.