An Immersive Experience in Medical Genomics

项目摘要 下一代测序(NGS)改变了基因组学领域，使其走在了基因组学的前沿 然而，医疗保健领域技术发展的快速步伐甚至向现场专家提出了挑战 与时俱进。成功地将基因组学应用于临床实践需要的不仅仅是 对这项技术的肤浅理解。建议开设的课程《身临其境的医疗体验》 基因组学“是为寻求在基因组学方面打下坚实基础的广大临床医生设计的，并将 组织结构以促进跨学科的协作和串扰。它建立在目前获得资金的基础上 在儿童慈悲医院(CMH)开发的计划，使用多模式教育方法，包括 个人基因组教育测试(PGET)，以吸引参与者参与基因组学和精确医学。这个 拟议课程的中心目标是促进将基因组医学落实到 临床实践。我们将通过以下具体目标来实现这一目标：1)创建灵活的教学 通过设计良好的电子学习模块、讲座、 以案例为基础的讨论和动手研讨会，2)教育课程参与者关于特殊的道德、法律和 基因组检测的社会影响(ELSI)，3)促进临床基因组研究与 传统的临床实践。对课程修改和影响的短期和长期影响将 通过学术活动(专题介绍和出版物)分发成果。这个 建议的课程将使儿科基因组医学中心(CPGM)能够分享我们的翻译 拥有250名临床医生的基因组专业知识，致力于将基因组指导的精确医学整合到 5年以上临床实践经验。

Project Summary Next generation sequencing (NGS) has transformed the field of genomics, bringing it to the forefront of healthcare, however the rapid pace of technological developments in the field challenges even field experts to stay current. The successful implementation of genomics into clinical practice requires much more than a superficial understanding of the technology. The proposed course, "An Immersive Experience in Medical Genomics" is designed for a broad audience of clinicians seeking a strong foundation in genomics, and will be structured to facilitate collaboration and crosstalk across disciplines. It builds upon the currently funded program developed at Children's Mercy Hospital (CMH) that uses a multimodal educational approach including Personal Genome Education Testing (PGET) to engage participants in genomics and precision medicine. The central goal of the proposed course is to facilitate the implementation of genomic medicine into all aspects of clinical practice. We will accomplish this goal through the following specific aims: 1) create a flexible teaching model to optimize genomic education through a combination of well-designed e-learning modules, lectures, case-based discussions, and hands on workshops, 2) educate course participants on special ethical, legal, and social implications (ELSI) of genomic testing, 3) to promote the integration of clinical genomic research into traditional clinical practice. Short and long-term impacts for purposes of curriculum modification and impact will be collected, with results distributed through scholarly activities (presentations and publications). The proposed course will enable The Center for Pediatric Genomic Medicine (CPGM) to share our translational genomic expertise with 250 clinicians, committed to the integration of genomic guided precision medicine into clinical practice, over 5 years.