Center for Translational Pediatric Research

总结 2017年7月，我们在阿肯色州启动了COBRE转化儿科研究中心的第一阶段 位于阿肯色州小石城的儿童研究所。该中心的使命是利用蛋白质基因组学 确定包括癌症在内的疾病中的表观基因组机制和治疗靶点的方法， 或可转移到儿科人群。中心成员研究的统一主题是利用 系统生物学方法和先进的生物信息学研究疾病机制。的目标 第一阶段是建立该中心的基础，扩大成功的研究人员与教师库 发展计划和支持系统级核心资源。为了实现这一目标，该中心成立了一个 4个研究项目负责人和2个研究核心，蛋白质组学核心和基因组学与生物信息学 核心通过使用由行政核心监督的指导教师发展计划， 第一阶段的研究人员获得了9项RPG级赠款，包括一项U 01奖。此外，我们还能够 “毕业生”都是第一阶段的研究核心，以自我可持续性。总体而言，在第一阶段的过去4年中，我们 在建立多学科专题研究中心方面取得了实质性进展， 扩大我们的中心成员，过渡到独立的核心资源，和校外资金- 展示了该中心如何在COBRE支持之外朝着长期可持续发展的方向发展。 在第一阶段的基础上，我们在第二阶段的目标是进一步加强我们的院校研究 基础设施，通过发展我们的多学科，专题研究中心，通过战略扩张， 研究人员的临界质量，投资于研究基础设施，并实施长期中心计划 COBRE支持之外的可持续性。我们将为最初的5人小组提供结构化的指导和支持 第二阶段研究项目负责人。此外，我们将通过以下方式扩大中心的研究人员队伍： 机构承诺招聘4名助理和1名副教授或正教授到中心。支持需求 在不断扩大的研究人员临界质量中，我们将开发一个新的蛋白质基因组学核心， 该中心不断发展的研究使命。这一独特的核心将提供研究项目负责人和其他 中心成员可以接触到经验丰富的人员，进行非标准蛋白质组学、基因组学和表观基因组学研究 应用程序，并获得高技能的生物信息学家的尖端数据分析和集成。到 为了支持调查人员的扩大和新的研究核心，行政核心将提供一个学院， 发展计划、试点项目计划、运营监督和领导，因为中心准备 过渡到长期可持续性。在第二阶段完成后，我们预计将有大量的初级， 职业生涯中期，以及该中心的高级研究人员，他们可以访问世界一流的系统生物学核心， 将使中心成员能够成功地竞争个人，多研究者和项目级赠款 支持该中心向COBRE支持之外的长期可持续性过渡。

Summary In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in diseases, including cancer, impacting or translatable to the pediatric population. The unifying theme of research among center members is utilizing systems biology approaches and sophisticated bioinformatics for studying disease mechanism. The goal of Phase I was to establish the foundation of the center, expand the pool of successful investigators with a Faculty Development Plan, and support systems-level core resources. Towards this goal, the center was created with a nucleus of 4 Research Project Leaders and 2 research cores, Proteomics Core and Genomics & Bioinformatics Core. Through use of a mentored Faculty Development Program overseen by the Administrative Core, the junior investigators from Phase I received 9 RPG-level grants, including an U01-award. Additionally, we were able to “graduate” both Phase I research cores to self-sustainability. Collectively, during the past 4 years of Phase I, we have made substantial progress towards establishing a multi-disciplinary, thematic research center through expansion of our center members, transitioning core resources to independence, and extramural funding – demonstrating how the center is moving in the direction of long-term sustainability beyond COBRE support. Building on the momentum of Phase I, our goals in Phase II are to further enhance our institutional research infrastructure by developing our multi-disciplinary, thematic research center through strategic expansion of the critical mass of investigators, investing into research infrastructure, and implementing a plan for long-term center sustainability beyond COBRE support. We will provide structured mentoring and support to an initial group of 5 Research Project Leaders in Phase II. Furthermore, we will expand the pool of investigators in the center through institutional commitments to recruit 4 Assistant and 1 Associate or Full Professor to the center. To support needs of the expanding critical mass of investigators, we will develop a new Proteogenomics Core that is essential for the evolving research mission of the center. This unique core will provide Research Project Leaders and other center members access to experienced personnel for non-standard proteomic, genomic, and epigenomic applications, and access to highly skilled bioinformaticians for cutting-edge data analysis and integration. To support the expansion of investigators and a new research core, the Administrative Core will provide a Faculty Development Plan, Pilot Project Program, operational oversight, and leadership as the center prepares to transition to long-term sustainability. Upon completion of Phase II, we anticipate having a critical mass of junior, mid-career, and senior investigators in the center who have access to world-class systems biology cores, which will enable center members to successfully compete for individual, multi-investigator, and program-level grants to support transition of the center to long-term sustainability beyond COBRE support.