Nathan Shock Center of Excellence in Basic Biology of Aging

整体项目总结 这份申请是为了续期内森·休克老年基础生物学卓越中心 在华盛顿大学及其附属机构。该中心在过去的25年里 为研究衰老生物学的研究人员提供了关键资源。此应用程序 继续强调向最广泛的调查人员社区提供外展和服务的主题 在老年学中。最密切相关的是与衰老相关的表型的特征 长寿健寿。由于我们的中心服务必须便于外部用户访问，我们的 长寿和健康核心(核心E)专注于无脊椎动物测试，其中许多都是新奇的。二 其他资源核心侧重于与老龄化密切相关的高维度评估 表型：衰老的蛋白质表型(核心C)和代谢产物的老化表型(核心D)。 提供复杂的计算和生物信息学工具，用于数据分析和最佳洞察 人工智能和生物信息学核心F。这四个资源核心中的每一个都由 该领域备受尊敬的专家，包括Michael MacCoss和Judit Villen(Core C)，Daniel Promislow(核心D)、Matt Kaeberlein和Maitreya Dunham(核心E)以及李秀英(核心F)。每个人 将突破适当技术的界限，开发新的最先进的方法 最适用于老年学的评估，并使国家可获得这些评估 老龄化社区。研究开发核心(核心B)将继续支持试点和初级 教员研究，坚定地把重点放在向国家老年科学群体提供服务上。这个 行政和计划丰富核心(核心A)支持行政管理，以及 外部咨询小组、课程以及数据共享和传播。核心A的研讨会计划 专题讨论会将继续侧重于赞助和组织国家课程、会议 和会前，以及与我们的资源核心服务相关的领域的研讨会。在……里面 与其他内森休克中心协调，我们将支持一项新的老年病理学研究 主动权。

OVERALL PROJECT SUMMARY This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and affiliated institutions. This Center has over the past 25 years provided key resources in support of investigators who study the biology of aging. This application continues a theme that emphasizes outreach and service to the broadest community of investigators in the gerosciences. Of proximal relevance is the characterization of aging-related phenotypes of longevity and healthspan. As our Center services must be easily accessible to outside users, our Longevity and Healthspan Core (Core E) focuses on invertebrate assays, many of them novel. Two other Resources Cores focus on the high dimensional assessments that are closely related to aging phenotypes: Protein Phenotypes of Aging (Core C) and Metabolite Phenotypes of Aging (Core D). Sophisticated computational and bioinformatic tools for data analysis and optimal insight are provided by the Artificial Intelligence and Bioinformatics Core F. Each of these four Resource Cores is led by highly respected experts in that field, including Michael MacCoss and Judit Villen (Core C), Daniel Promislow (Core D), Matt Kaeberlein and Maitreya Dunham (Core E) and Su-In Lee (Core F). Each will push the envelope of appropriate technologies, developing new state-of-the art approaches for assessments that are the most applicable to gerontology and making them accessible to the national aging community. The Research Development Core (Core B) will continue to support pilot and junior faculty studies, with a firm focus on outreach of service to the national geroscience constituency. The Administrative and Program Enrichment Core (Core A) supports administrative management, an external advisory panel, courses, and data sharing and dissemination. Core A’s program of seminars and symposia will continue a focus on sponsorship and organization of national courses, meetings and pre-meetings, as well as workshops in the fields allied to our Resource Core Services. In coordination with other Nathan Shock Centers, we will support a new Geropathology Research initiative.