Biostatistics Core

生物统计学核心 项目摘要 生物统计学和生物信息学核心（“BB核心”）资源将提供全面的生物统计学 为拟议的约翰霍普金斯骨髓研究中心的所有研究项目提供咨询和合作 人类疾病移植计划项目补助金。此外，它还将为数据存储提供支持， 信息学和计算，并协助识别和解决复杂的数据任务， 项目活动的过程。核心成员将与项目调查人员合作， 活动，包括数据采集（包括研究设计、目标的可行性、公共信息的可用性、 访问基因组信息和数据存储），统计质量控制（包括伪影检测和 来自基因组技术的数据的预处理），数据分析（包括可视化，生物统计建模， 和协助撰写手稿），以及开发创新的定制生物统计学， 生物信息学方法和工具（如具体项目需要）。生物统计学的核心资源是 位于约翰霍普金斯大学肿瘤学系生物统计学和生物信息学部 医学院。该司由一个积极和致力于生物统计学和生物信息学的小组组成。 教师，以及非教师生物统计学家和生物信息学家，可以使用最先进的设备 和广泛的专业知识。这一核心资源是长期资源的延续， 正在进行BMT P01。核心成员对P01的坚定承诺源于30多年来 与BMT项目的合作。所有拟议的项目都在每个目标中利用这一核心资源。 BB核心的主要目标是指导和协助项目调查人员设计、实施、 以及本P01中拟定的实验室和临床研究的分析。这个核心由拉维·瓦拉德汉博士领导 副教授，肿瘤生物统计学和生物信息学。核心的工作重点是协助 临床和实验室研究者将其临床前研究转化为临床研究， 最先进的实验设计和分析，通过统计咨询和合作， 关于临床和实验室研究的方法学、可行性、安全性监测、分析和报告。 30多年来，BB核心一直是并将继续是研究的一个组成部分， P01应用程序的各个项目的完成情况。

Biostatistics Core Project Summary The Biostatistics and Bioinformatics Core (“BB Core”) Resource will provide comprehensive biostatistics consultation and collaboration to all Research Projects in the proposed Johns Hopkins Bone Marrow Transplantation in Human Disease Program Project Grant. In addition, it will provide support for data storage, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public- access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistics and bioinformatics methodologies and tools if required by specific projects. The Biostatistics Core Resource is housed in the Division of Biostatistics and Bioinformatics, Department of Oncology at Johns Hopkins University School of Medicine. This Division comprises an active and committed group of biostatistics and bioinformatics faculty, as well as non-faculty biostatisticians and bioinformaticians, with access to state-of-the art equipment and a broad range of expertise. This Core Resource is the continuation of the long-standing resource within the ongoing BMT P01. Core members have a strong commitment to this P01, stemming from more than 30 years of collaboration with the BMT program. All proposed Projects make use of this Core Resource in every Aim. The primary objective of the BB Core is to guide and assist the project investigators in the design, conduct, and analysis of the laboratory and clinical studies proposed in this P01. This core is led by Dr. Ravi Varadhan, Associate Professor, Oncology Biostatistics and Bioinformatics. The Core focuses its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinical studies into clinical studies by providing state-of-the-art experimental designs and analyses through statistical consultation and collaboration with respect to methodology, feasibility, safety monitoring, analysis, and reporting of clinical and laboratory studies. For more than 30 years, the BB core has been and continues to be an integral part of the research accomplishments of the individual projects of this P01 application.