The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence

项目总结 该奖学金的目标是使申请者西娅·森格-卡彭特成为一名研究护士的科学家。 青少年睡眠、不良童年经历(ACE)和相关症状与 结果。为此，拟议的研究金由两个相辅相成的部分组成：(1)培训计划 包括正式培训、指导、实践研究、手稿出版和专业 发展活动和(2)一个研究项目，将加深我们对睡眠如何影响睡眠的理解 持续或复发性疼痛(PRP)与ACEs、心理健康症状的关系 青春期。申请者将得到一个强大的导师团队的支持，该团队由加州大学的赞助商组成。 密歇根护理学院和耶鲁护理学院。导师团队共同提供以下方面的专业知识 青少年睡眠、疼痛和相关症状，以及ACE暴露。这项培训计划将有助于 申请者培养：a)在青少年睡眠、PRP和ACE暴露的后遗症方面的专业知识，b) 具有纵向、多变量数据分析的方法技能；c)参与研究的传播 调查结果和专业网络活动。 睡眠不足影响多达三分之二的美国青少年，是PRP、焦虑和 抑郁症。ACE暴露同样普遍，影响到大约一半的美国青少年，并与 既有PRP症状又有心理健康症状。重要的是，睡眠不足可能会减缓血管紧张素转换酶的效果 暴露在其他健康后果上。然而，人们对睡眠不足如何影响睡眠质量知之甚少。 青春期ACE暴露、精神健康症状和PRP之间的关系 恋爱关系因种族、民族、社会经济地位(SES)和性别而异。因此，拟议的 项目是1)确定睡眠不足是否以及如何缓和ACE对PRP的间接影响 通过精神健康症状和2)描述这些关系如何按种族、民族、SES和 性。所有目标都将通过正在进行的美国国立卫生研究院青少年大脑认知发展研究进行调查。 资助对美国青年发展的纵向研究。 该项目融合了健康公平和人口与社区健康的研究视角。 在国家护理研究所的战略计划中概述了这一点。通过将睡眠识别为可修改的 作为干预的目标，我们的研究结果有可能减轻暴露于 ACES和减少基于种族、民族、社会经济和性别的健康结果不平等。

PROJECT SUMMARY The goal of this fellowship is to prepare the applicant, Thea Senger-Carpenter, as a nurse-scientist studying relationships among adolescent sleep, adverse childhood experiences (ACEs), and associated symptoms and outcomes. To that end, the proposed fellowship consists of two complementary components: (1) a training plan comprising formal training, mentorship, hands-on research, manuscript publication, and professional development activities and (2) a research project that will further our understanding of how sleep affects the relationships among ACEs, mental health symptoms and persistent or recurrent pain (PRP) during adolescence. The applicant will be supported by a strong mentorship team with sponsors at the University of Michigan School of Nursing and Yale School of Nursing. Together, the mentorship team provides expertise in adolescent sleep, pain and associated symptoms, and ACE exposure. The training program will help the applicant develop: a) expertise in adolescent sleep, PRP, and the sequelae of ACE exposure, b) methodological skills in longitudinal, multivariate data analysis and c) engage in the dissemination of research findings and professional networking activities. Sleep deficiency affects up to two-thirds of American adolescents and is a risk factor for PRP, anxiety, and depression. ACE exposure is similarly prevalent, affecting around half of U.S. teens, and has been associated with both PRP and mental health symptoms. Importantly, sleep deficiency may moderate the effect of ACE exposure on other health outcomes. However, little is known about how sleep deficiency impacts the relationships among ACE exposure, mental health symptoms, and PRP across adolescence nor how these relationships differ by race, ethnicity, socioeconomic status (SES), and sex. Thus, the aims of the proposed project are 1) to determine whether and how sleep deficiency moderates the indirect effect of ACEs on PRP through mental health symptoms and 2) to describe how these relationships differ by race, ethnicity, SES, and sex. All aims will be investigated using the Adolescent Brain Cognitive Development Study, an ongoing NIH- funded longitudinal study of youth development in the United States. This proposed project integrates the research lenses of health equity and population and community health outlined in the National Institute of Nursing Research's strategic plan. By identifying sleep as a modifiable target for intervention, our findings have the potential to reduce the symptom burden of adolescents exposed to ACEs and mitigate racial, ethnic, socioeconomic, and sex-based inequities in health outcomes.