Next-Gen Oncopathology Program

下一代肿瘤病理学（NGO）计划的总体使命是培训年轻的诊断医生， 我们对癌症发病机制的理解和新的肿瘤干预措施的进展 从而引领病理学领域走向未来。专业的病理学家已经介入 至少从世纪开始，通过检查组织和其他标本进行癌症诊断， 病理学已经逐渐结构化和亚专业化。病理学培训项目传统上教 住院医生在显微镜下检查组织，分析实验室数据进行诊断， 研究主要是描述性的。这种做法已经不够了，我们必须做好准备， 病理学家了解和应用先进的技术，以执行更精确和个性化 除了利用创新和改进的方法来进行研究和诊断癌症之外，还可以进行诊断。的 威尔康奈尔病理学和实验室医学系培养了众多优秀的病理学家 在许多亚专业领域，但只有使用创新的方法， 未来，我们将能够产生领导者，将推动癌症病理学领域。非政府组织 该计划采取全面和多学科的方法，考虑癌症患者的各个方面， 从肿瘤本身，到体外和体内癌症模型，到患者血液的变化， 微生物感染因此，解剖学和临床病理学（即实验室医学）的学员将 包括具有医学博士或医学博士/博士学位的病理学住院医师或研究员，或 具有博士学位的实习生在实验室医学中进行临床研究，他们致力于学术研究， 包括癌症研究在内的职业生涯。我们的学员将获得专业知识和深度，通过花两年时间在一个 研究实验室工作在一个或多个以下主要主题：1）分子诊断和细胞 治疗，2）癌症病理生物学，3）先进的成像和4）肿瘤微环境。科学命题制订的理论 非政府组织计划的原则是确保所有病理学项目都与癌症研究有关 患者样品以及癌症模型的比较病理学。全面的方法， 支持所有项目的是：i）生物统计学和数据科学，ii）机器学习和人工智能，以及 基因组学、表观基因组学、蛋白质组学和代谢组学。该计划的教师在该专业有专业知识 主题和具体的方法，这将允许基础技能的教学，以及一个高度 定制的教育计划。为此，将开设非政府组织必修课程， 以及关于数据科学和职业发展的额外课程要求，这将使学员能够 灵活地与他们的指导委员会设计个性化的课程。我们还将利用迈耶 癌症中心和威尔康奈尔临床和转化科学中心（CTSC）的资源，以教育 下一代癌症病理学家

The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologists have been involved in cancer diagnostics by examining tissues and other specimens since at least the 19th century, and training in pathology has been incrementally structured and subspecialized. Pathology training programs traditionally teach residents to examine tissue under the microscope and analyze laboratory data for diagnosis, with pathology research being largely descriptive. This approach is no longer sufficient, and it is essential that we prepare pathologists to understand and apply advanced technologies to perform more precise and personalized diagnostics in addition to utilizing innovative and improved ways to conduct research and diagnose cancer. The Weill Cornell Department of Pathology and Laboratory Medicine has trained numerous outstanding pathologists in many subspecialty areas, but it is only with the use of an innovative approach incorporating a view towards the future that we will be able to produce leaders that will advance the field of cancer pathology. The NGO program takes a holistic and multidisciplinary approach, where all aspects of a cancer patient are considered, ranging from the tumors themselves, to in vitro and in vivo cancer models, to changes in the patients’ blood and microbial infections. Thus, trainees in both Anatomic and Clinical Pathology (i.e. Laboratory Medicine) will be included, which will be individuals with MD or MD/PhD degrees doing a Pathology Residency or Fellowship, or trainees with PhD degrees doing a clinical fellowship in Laboratory Medicine, who are committed to an academic career that includes cancer research. Our trainees will gain expertise and depth by spending two years in a research laboratory working in one or more of the following major themes: 1) molecular diagnosis and cellular therapies, 2) cancer pathobiology, 3) advanced imaging and 4) tumor microenvironment. The foundational principles of the NGO program will be to ensure that all the pathology projects relate to the study of cancer patient samples as well as the comparative pathology of cancer models. Overarching methodologies that will support all of the projects are: i) biostatistics and data science, ii) machine learning and artificial intelligence, and iii) genomics, epigenomics, proteomics and metabolomics. Faculty in the program have expertise in the major themes and specific methodologies, which will allow for the teaching of foundational skills as well as a highly customized educational plan. This will be accomplished by the establishment of a mandatory NGO Course as well as additional course requirements on data science and career development, which will allow trainees flexibility to design a personalized curriculum with their mentoring committee. We will also leverage the Meyer Cancer Center and the Weill Cornell Clinical and Translational Science Center (CTSC) resources to educate the next generation of pathologists working on cancer.