The Aga Khan University Pakistan Initiative for Non-Communicable Diseases (AKUPI-NCDs) Research Training Program

项目摘要 非传染性疾病是一场非同寻常的全球危机。在所有非传染性疾病中， 非传染性疾病相关的过早死亡和82%的非传染性疾病相关的过早死亡发生在中低收入国家。 有关非传染性疾病的地方相关高质量数据稀缺，大多数中低收入国家 像巴基斯坦这样的国家没有能力控制这种流行病。低收入国家在应对非传染性疾病方面存在重大差距 缺乏训练有素的研究人员，他们可以帮助理解流行病，风险因素， 开发和测试安全、有效和低成本的解决方案。我们之前的工作是通过D 71资助的 PAR-17-097机制在2018年，表明存在迫切的地方和国家的需要和愿望， 高素质、多学科、训练有素的专业人员领导以非传染性疾病为主题的小组 巴基斯坦的研究。我们能够确定高度优先的非传染性疾病研究主题和最合适的研究 培训资源和途径。根据这些独特的见解，我们设计了一个全面的， 综合的，多学科的培训计划，以培养下一代领导人在非传染性疾病研究与 特别关注心脑血管疾病及其共同风险因素。培训计划 利用阿加汗大学（AKU）和全球健康与发展研究所的广泛 开发网络平台和基础设施在其旗舰网站在巴基斯坦。具体目标是 （a）高质量地监测危险因素（包括 社会决定因素），（B）实施对环境敏感的， 可扩展的方法来预防和管理巴基斯坦的心脑血管疾病。的重 重点将是利用包括大数据和移动保健在内的数字信息技术的研究方法。 2)建立一个可持续的巴基斯坦心神经血管疾病监测研究专家库， 实施科学谁将提供必要的远见和领导，以产生高质量的研究 这对巴基斯坦和其他低收入国家防治非传染性疾病具有重要意义。拟议的计划汇集了教师， 来自巴基斯坦卡拉奇的阿加汗大学和杜克大学的研究专长和资源， 美国的我们预计，这一计划将直接提高巴基斯坦的研究能力，这是一个关键的 这是国家非传染性疾病综合对策的一个要素。 1

PROJECT SUMMARY Non-communicable diseases (NCDs) represent an extraordinary global crisis. Over three quarters of all NCD related deaths and 82% of premature NCD-related deaths occur in low-middle income countries (LMIC). Locally-relevant, high-quality data regarding NCDs are scarce and most low-middle income countries (LMICs) like Pakistan, are not equipped to manage this epidemic. A critical gap in the response of LMICs to the NCD epidemic is a dearth of trained researchers who can contribute to the understanding of prevalence, risk factors, and development and testing of safe, effective, and low-cost solutions. Our prior work funded through the D71 PAR-17-097 mechanism in 2018, shows that there exists a pressing local and national need and desire for high-quality, multidisciplinary, trained professionals to lead teams that are thematically focused on NCD research in Pakistan. We were able to identify high-priority NCD research themes and most suitable research training resources and pathways. Informed by these unique insights we have designed a comprehensive, integrated, multi-disciplinary training program to train the next generation of leaders in NCD research with a particular focus on cardio-cerebrovascular diseases and their shared risk factors. The training program leverages the Aga Khan University’s (AKU) and the Institute for Global Health and Development extensive development network platform and infrastructure at its flagship site in Pakistan. The specific aims of this program are to: 1) Build sustainable research capacity in: (a) high-quality surveillance of risk factors (including social determinants) across the life span common to several NCDs, (b) implementation of context sensitive, scalable, approaches to cardio-cerebro vascular diseases prevention & management in Pakistan. A heavy focus will be research approaches that leverage digital information technology including big data and m-health. 2) Develop a sustainable pool of Pakistani research experts in cardio-neurovascular disease surveillance and implementation science who will provide the vision and leadership necessary to produce high-quality research of relevance to tackling NCDs in Pakistan and other LMICs. The proposed program brings together faculty, research expertise, and resources from the Aga Khan University, Karachi, Pakistan and Duke University, United States. We expect that this program will directly increase Pakistan’s research capacity, a critical element in a comprehensive national NCD response. 1