PROMIS to explore Burden and Stress in Cancer Caregivers

这项纵向的自然历史研究的主要目的是检验在积极治疗期间收集癌症患者无偿非正式照顾者一段时间内基于网络的患者报告结果(PRO)的可行性。此外，我们将研究癌症患者无偿非正式照顾者在积极治疗期间的自我效能、互动性、心理因素(压力、负担和孤独)、健康行为(健康促进生活方式简档II(HPLP)、吸烟、饮酒)和健康结果(睡眠、疲劳、焦虑、抑郁和认知功能)之间的相互关系。这项研究的主要目标是检验在无偿照顾者中收集基于网络的专业人员的可行性。需要129名完成至少一个时间点的受试者样本，才能对计划的初步分析进行充分评估，并评估主要目标。招聘于2014年2月开始，2016年7月结束招生。评估在癌症患者照顾者中使用电子患者报告结局(EPRO)收集系统的可行性的初步发现发表在《精神病学》杂志上，27(4)，1350-1352。DOI：10.1002/Pon.4658.我们共招募了139名受试者，其中129人完成了时间点#1，85人完成了时间点#2，61人完成了时间点#3。分析的传播正在进行中。

The primary purpose of this longitudinal, natural history study is to examine the feasibility of collecting web-based patient-reported outcomes (PROs) over time in unpaid informal caregivers of cancer patients during the active treatment period. Additionally, we will examine the interrelationships between self-efficacy, mutuality, psychological factors (stress, burden, and loneliness), health behaviors (Health Promoting Lifestyle Profile-II (HPLP), smoking, alcohol consumption), and health outcomes (sleep, fatigue, anxiety, depression, and cognitive function) in unpaid informal caregivers of cancer patients during the active treatment period. The primary objective of this study is to examine the feasibility of collecting web-basd PROs over time in unpaid caregivers. A sample of 129 subjects completing at least one time point is required to adequately evaluate for the planned primary analysis and evaluate the primary objectives. Recruitment began in February 2014 and closed to enrollment in July 2016. The primary findings, Assessing the feasibility of an electronic patient-reported outcome (ePRO) collection system in caregivers of cancer patients was published in the journal Psychooncology,, 27(4), 1350-1352. doi:10.1002/pon.4658. We enrolled a total of 139 subjects, with n=129 with time point #1 completed, n=85 with time point #2 completed, and n=61 with time point #3 completed. Dissemination of analysis are on-going.