Developmental Research Program

项目摘要 胰腺癌发展研究计划（DRP）的目标是招募和支持 胰腺癌的发展研究项目，以便将来作为完整的SPORE项目或作为 申请其他国家竞争性同行评审资金的基础。胰腺癌的早期症状 支持的研究项目包括基础、转化、临床、流行病学和癌症 预防研究成果评审计划资助的项目将扩大转化研究的范围， 致力于胰腺癌研究的研究人员人数。DRP是开放给机构参与 在孢子（WUSM，宾夕法尼亚大学）和他们的任何合作者。DRP将与职业发展部合作， 增强计划（CEP），以协助发展初级调查员和招募/指导少数族裔 investigators.这些目标将通过实现四个具体目标来实现。 目标1：支持胰腺癌研究项目的发展，以便将来全面纳入 SPORE项目或新的独立同行评审资金。DRP将征集新的研究项目 每年。除了国家癌症研究所的资金外，还承诺提供共计375 000美元的机构支助， 的DRP。DRP奖励将提供高达75，000美元的1年，允许第二次竞争性续订 年融资。预计每年颁发两至三个奖项。机构基金将使NCI基金 （25，000美元/年）致力于代表性不足的少数民族，相当于其他DRP奖项。 目标2：促进基础和临床研究人员之间的合作。DRP董事将促进 基础和临床研究人员之间的互动，通过共享每周会议，年度孢子务虚会， 和小组会议。 目标3：指导参与胰腺癌研究的初级教师和新教师。所有研究者 向DRP提交申请将收到一份书面的科学和统计审查，DRP主任 将详细讨论这些项目。在适当的情况下， 教师或与教师合作，其主要研究领域是胰腺癌以外。所有DRP获奖者 将每年两次向SPORE指导委员会介绍他们的研究进展。 目标4：促进女性、少数民族和残疾人参与胰腺癌研究 研究和促进招募少数民族参与胰腺癌临床试验。的DRP 主任们将实施促进妇女、少数民族和残疾人参与的倡议， 开展临床试验，促进不同群体参与胰腺癌研究。 影响：拟议的工作将提高我们对胰腺癌生物学的理解，并将确定新的 早期发现，预防，成像和治疗这种难治性恶性肿瘤的策略。

PROJECT SUMMARY The goal of the SPORE in Pancreatic Cancer Developmental Research Program (DRP) is to recruit and support developmental research projects in pancreatic cancer for future incorporation as full SPORE projects or as the basis for applications for other nationally competitive peer-reviewed funding. The types of pancreatic cancer research projects that will be supported include basic, translational, clinical, epidemiologic, and cancer prevention. Projects supported under the DRP will expand the scope of translational research and increase the number of investigators committed to pancreatic cancer research. The DRP is open to institutions participating in the SPORE (WUSM, UPenn) and any of their collaborators. The DRP will work in tandem with the Career Enhancement Program (CEP) to assist in developing junior investigators and recruiting/mentoring minority investigators. These objectives will be accomplished by performing four specific aims. Aim 1: Support the development of pancreatic cancer research projects for future incorporation as full SPORE projects or for new independent peer-reviewed funding. The DRP will solicit new research projects annually. In addition to NCI funds, a total of $375,000 in institutional support has been committed in support of the DRP. DRP awards will provide up to $75,000 for 1 year, with a competitive renewal allowed for a second year of funding. Two to three awards per year are anticipated. Institutional funds will make the NCI funds ($25,000/year) committed to underrepresented minorities equivalent to other DRP awards. Aim 2: Foster collaborations between basic and clinical researchers. The DRP directors will facilitate interactions between basic and clinical researchers through shared weekly meetings, the annual SPORE retreat, and small group meetings. Aim 3: Mentor junior faculty and new faculty involved in pancreatic cancer research. All investigators submitting applications to the DRP will receive a written scientific and statistical review, and the DRP directors will be available to discuss the projects in detail. Where appropriate, mentors will be identified to work with junior faculty or collaborate with faculty whose primary research area is outside of pancreatic cancer. All DRP awardees will present their research progress to the SPORE steering committee twice per year. Aim 4: Promote the participation of women, minorities, and disabled investigators in pancreatic cancer research and facilitate the recruitment of minorities into clinical pancreatic cancer trials. The DRP directors will implement initiatives that enhance the participation of women, minorities, and disabled persons in SPORE clinical trials and promote the participation of diverse groups in pancreatic cancer research. Impact: The proposed work will improve our understanding of pancreatic cancer biology and will identify new strategies for early detection, prevention, imaging, and treatment for this refractory malignancy.