RTI HEAL Harm Reduction Network Coordination Center

项目总结/摘要 过量用药危机的严重性使人们更加关注一个众所周知的公共卫生工具 被称为伤害减少-一套策略或计划，实施，以减少负面的 与使用类阿片和其他药物有关的后果，同时保持对 单独的.认识到减少危害对解决目前的类阿片危机的重要性， 物质使用障碍更广泛，美国国立卫生研究院（NIH），通过帮助结束 成瘾长期（HEAL）倡议，打算推出一个减少伤害网络（HRN）的九项研究 项目和一个协调中心（CC），以提高对有效性和成果的理解， 实施减少危害战略。RTI提议担任HRN的CC。在这方面， RTI将为HRN提供科学、行政和后勤支持，以促进网络协调 沟通（目标1）认识到数据协调对于减少危害研究的重要性， RTI将促进开发通用指标和措施的企业参与过程，以支持 HEAL数据协调、数据基础设施和共享，并提供方法咨询（目标2）。 鉴于必须让利益攸关方发表意见，以充分查明具体国家面临的问题， 人口，并为他们提供基于证据的解决方案，RTI将促进概念驱动的 利益攸关方的参与，代表相关危害风险最高的个人和社区 与吸毒有关（目标3）。为了加速将研究成果转化为实践，RTI将建立一个 促进翻译产品及时开发和传播的研究基础设施， 包括通过以用户为中心的设计（目标4）的有效传播策略。我们的CC团队由 Emmanuel Oga博士和Jessica Cance博士，他们是经验丰富的领导者， 最大的现有NIH HEAL多站点努力。更广泛的核心领导者、合作研究者和科学家团队 顾问在减少危害、数据协调、统计方法、数据 基础设施发展和管理以及实施科学。RTI拥有丰富的经验 成功地运行CC，并在物质使用研究方面保留了大量的集体专业知识， 减少和社区参与，以实施一系列科学和支持活动， 网络RTI CC将提供所需的强大的中央操作，以协调全面的 多项目，多管齐下的研究奋进，证明了对方法论的理解 整合来自不同人群和结果的多个来源的证据的复杂性。

Project Summary/Abstract The magnitude of the overdose crisis has brought an increased focus to a well-known public health tool referred to as harm reduction—a set of strategies or programs implemented to reduce the negative consequences associated with the use of opioids and other substances while maintaining respect for the individual. Recognizing the importance of harm reduction in addressing the ongoing opioid crisis and substance use disorder more broadly, the National Institutes of Health (NIH), through the Helping to End Addiction Long-term (HEAL) initiative, intends to launch a Harm Reduction Network (HRN) of nine research projects and a Coordination Center (CC) to improve understanding of the effectiveness and outcomes of implementation of harm reduction strategies. RTI proposes to serve as the CC for the HRN. In this capacity, RTI will provide scientific, administrative, and logistical support for the HRN to facilitate network coordination and communication (Aim 1). Recognizing the importance of data harmonization for harm reduction research, RTI will facilitate a stakeholder-engaged process of developing common metrics and measures to support HEAL data harmonization, data infrastructure and sharing, and provide methodology consultations (Aim 2). Given the importance of involving stakeholder voices to adequately identify the problems faced by specific populations and serve them with evidence-based solutions, RTI will facilitate a conceptually driven engagement of stakeholders representing individuals and communities at highest risk for harms associated with drug use (Aim 3). To accelerate the translation of research findings into practice, RTI will establish a research infrastructure that facilitates the timely development and dissemination of translational products, including effective dissemination strategies through user-centered design (Aim 4). Our CC team is led by multiple Principal Investigators Drs. Emmanuel Oga and Jessica Cance, who are experienced leaders of the largest existing NIH HEAL multisite efforts. The broader team of Core leaders, co-investigators, and scientific advisors bring significant expertise in harm reduction, data harmonization, statistical methodology, data infrastructure development and management, and implementation science. RTI has extensive experience successfully running CCs and retains substantive collective expertise in substance use research, harm reduction, and community engagement to implement a portfolio of scientific and support activities for the network. The RTI CC will provide the needed robust central operation to coordinate a comprehensive multiproject, multipronged research endeavor that demonstrates an understanding of the methodological complexities of integrating evidence from multiple sources with diverse populations and outcomes.