Admin/Coordination Core

摘要 行政/协调核心(行政协调会)的目标是提供行政领导，并保证所有 UCI亚单位正在有效地相互作用和通信。与其他财团成员整合， 印第安纳大学(IU)/杰克逊实验室(JAX)/匹兹堡大学(匹兹堡)以及Sage 生物网络和国家老龄研究所(NIA)也是行政协调会的主要目标。作为领导层 UCI模式的核心-AD，我们的目标是通过管理和支持不同的 核心，以开发和表征新的迟发性阿尔茨海默病(LOAD)小鼠模型 以便有效地将它们分发给科学界。在过去的五年中，行政协调会成功地 通过以下方式促进产生阿尔茨海默病(AD)新小鼠模型的创新方法 为疾病建模项目(DMP)核心以及生物信息学和数据提供必要的支持 管理核心(BDMC)(现在称为功能基因组学和生物信息学数据管理核心 [FGBDMC])。此外，在这款U54的第一次迭代中生成的所有鼠标模型现在都可以使用 通过我们的合作伙伴JAX，对学术和非学术科学界没有限制；以及数据 从这些小鼠模型的深度表型中获得的信息通过我们与 赛奇生物网络公司。LaFerla博士、Tenner博士和Green博士以及 他们管理多名调查员拨款的丰富经验，一直是UCI Model-AD的宝贵资产， 使所有核心领导和人员之间和谐、开放的沟通和协作。 它们与指导委员会以及外部咨询委员会(EAB)的持续互动，通过 由行政协调会组织的定期会议将帮助核心领导人确定新一代鼠标的优先顺序 并选择最有希望的模型进行深入的表型鉴定。作为主要目标之一 U54的目的是传播知识，行政协调会还将协调UCI模式-AD的参与 几次国际科学会议，包括由美国国家航空航天局组织的会议。总而言之，ACC将扮演 作为这个项目的管理引擎的关键作用，最终将确保它的成功。

ABSTRACT The goal of the Admin/Coordination Core (ACC) is to provide administrative leadership and to guarantee that all UCI subunits are interacting and communicating efficiently. Integration with the other consortium members, Indiana University (IU)/The Jackson Laboratory (JAX)/University of Pittsburgh (Pitt) as well as with Sage Bionetworks and the National Institute on Aging (NIA) are also key objectives for the ACC. As the leadership core of UCI MODEL-AD, our goal is to ensure the success of the project by managing and supporting the different cores in order to develop and characterize novel Late-Onset Alzheimer’s Disease (LOAD) mouse models as well as to efficiently distribute them to the scientific community. During the past five years, the ACC has successfully promoted innovative approaches for the generation of new mouse models of Alzheimer’s Disease (AD) by providing necessary support to the Disease Modeling Project (DMP) Core and the Bioinformatics and Data Management Core (BDMC) (now called the Functional Genomics and Bioinformatics Data Management Core [FGBDMC]). Moreover, all mouse models generated during the first iteration of this U54 are now available through our partner, JAX, with no restrictions to academic and non-academic scientific community; and the data obtained from the deep phenotyping of these mouse models is publicly available through our partnership with Sage Bionetworks. The innovative leadership style of the Co-PIs, Drs. LaFerla, Tenner and Green, as well as their strong experience managing multi-investigator grants, has been a valuable asset to UCI MODEL-AD, leading to a harmonious and open communication and collaboration among all the core leaders and personnel. Their continuous interactions with the Steering Committee as well as the External Advisory Board (EAB), via recurrent meetings organized by the ACC, will help the core leaders to prioritize the generation of new mouse models and select the most promising ones for a deep phenotyping characterization. As one of the main goals of U54 is the dissemination of knowledge, the ACC will also coordinate the participation of UCI MODEL-AD in several international scientific meetings, including those organized by the NIA. In summary, the ACC will play the key role of being the management engine for this project and will ultimately ensure its success.