Oligopyrrole-based Anion Binding Agents

该项目的长期目标是使用聚吡咯基阴离子受体， 了解调节阴离子识别和运输过程的基本因素 在生物学中，并开发可用于诊断和治疗 人类疾病这个为期两年的项目主要涉及：1）高- 在水的存在下允许阴离子识别的亲和受体，特别是 那些靶向氯化物和磷酸盐的试剂，以及2）使用这些试剂来产生新的聚合物 具有阴离子特异性识别特性的系统，并证明这些后者 聚合物可用于在界面下螯合磷酸根和其它阴离子， 条件重点将是杯吡咯和吡咯酰胺受体，依赖于多个 供体组并且利用新的阴离子识别基序（例如，CH-阴离子 氢键、局域电荷和离子配对相互作用）和受控几何结构 （例如，通过捆扎一个接收器面来实现）以实现所需的高度 亲和性，同时允许官能化和聚合。 预计到这个为期两年的项目完成时，一套新的 基于聚合物的萃取剂将在手，然后可以进一步开发， 用于控制终末期肾病，其中磷酸根阴离子的去除代表 重要的未解决的问题。

The long-range goals of this project are to use polypyrrole-based anion receptors to understand the fundamental factors that regulate anion recognition and transport processes in biology and to develop synthetic systems that are useful in the diagnosis and treatment of human disease. This two-year project is concerned specifically with 1) the design of high- affinity receptors that will allow for anion recognition in the presence of water, especially those targeting chloride and phosphate, and 2) using these agents to create new polymeric systems with anion-specific recognition properties and demonstrating that these latter polymers may be used for the sequestration of phosphate and other anions under interfacial conditions. The focus will be on calixpyrrole and pyrrole-amide receptors that rely on multiple donor sets and which take advantage of new anion recognition motifs (e.g., CH-anion hydrogen bonds, localized charges,and ion-pairing interactions) and controlled geometries (achieved through strapping one receptor face, for instance) to achieve the requisite high affinity while still. Permitting functionalization and polymerization. The expectation is that by the time this two-year project is complete, a new set of polymerbased extractants will be in hand that could then be developed further for eventual use in the control of end-stage renal disease, where phosphate anion removal represents an important unsolved problem.