Medicinal Inorganic Chemistry ACS Symposium F-2003

药物无机化学 ACS 研讨会 F-2003

• 批准号: 6703453
• 负责人: Jonathan L Sessler
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6703453
• 关键词: chemistry; chromium; free radicals; ion transport; ions; meeting /conference /symposium; metalloproteins; metals; radionuclide imaging /scanning; travel; vanadium

DESCRIPTION (provided by applicant): Funds are requested to defray in part the travel, registration, and local expenses of participants in the Medicinal Inorganic Chemistry (MIC) symposium to be held at the Fall American Chemical Society (ACS) meeting in New York, NY, September 9-11, 2003. This symposium, the first of its kind, is sponsored jointly by the Inorganic Chemistry and the Medicinal Chemistry Divisions of the ACS. It is intended to extend and support the newly initiated set of Gordon Conferences of the same name (MIC-GRC) that were inaugurated at Colby-Sawyer College in July 2002 and which are planned for the same venue in July of 2004. As has been true for the MIC-GRC meetings, the purpose of the MIC-ACS symposium is to outline the state-of-the-art in the field, from drug design to development to clinical trials, present up-to-the-minute research on metal-containing systems of medical importance, and foster the formation of new collaborative research efforts in the field. However, the symposium is designed to have a higher teaching component and be substantially more inclusive than the GRC's. In particular, whereas, the MIC-GRC meetings are designed to bring together established experts for high level (and formally confidential) discussions, a prime goal of the present MIC-ACS symposium is to attract new researchers to the area and provide them with an understanding of what is needed to conduct research on metal-based pharmaceutical agents. Thus, unlike the MIC-GRC, the MIC-ACS symposium will feature a tutorial session designed to show what is necessary to bring a putative metal-based drug substance from the laboratory to the point of initial clinical trials. Specific topics to be emphasized in this symposium include 1) the role of metal-generated radicals in health and disease; 2) metalloproteins in health and disease; 3) metalloproteins as drug targets; 4) transport of metals and metal complexes; 5) magnetic resonance imaging agents; 6) metal ions, metal complexes and malaria; 7) radioimaging agents; 8) vanadium and chromium in health and disease and, 9) metal ion-nucleic acid interactions. This mixture of topics, which will be covered through a series of research lectures designed to complement the tutorial session, as well as through poster sessions. It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission.

描述（由申请人提供）：申请资金用于支付2003年9月9日至11日在纽约州纽约举行的秋季美国化学学会（ACS）会议上举行的药用无机化学（MIC）专题讨论会与会者的部分差旅费、注册费和当地费用。 本次研讨会是由美国化学会无机化学和药物化学部联合主办的。它的目的是扩大和支持新发起的一系列同名戈登会议（MIC-GRC），该会议于2002年7月在科尔比-索耶学院开幕，计划于2004年7月在同一地点举行。与MIC-GRC会议一样，MIC-ACS研讨会的目的是概述该领域的最新技术，从药物设计到开发再到临床试验，介绍对医学重要性的含金属系统的最新研究，并促进该领域新的合作研究工作的形成。然而，研讨会的目的是有一个更高的教学组成部分，并大大超过GRC的包容性。特别是，而MIC-GRC会议的目的是汇集高级别（和正式保密）讨论的专家，目前MIC-ACS研讨会的主要目标是吸引新的研究人员到该地区，并为他们提供了什么是需要进行研究的金属为基础的药剂的理解。因此，与MIC-GRC不同的是，MIC-ACS研讨会将设有一个指导会议，旨在展示将假定的金属基原料药从实验室带到初步临床试验的必要条件。本次研讨会将重点讨论的具体议题包括：1）金属产生的自由基在健康和疾病中的作用; 2）金属蛋白在健康和疾病中的作用; 3）金属蛋白作为药物靶点; 4）金属和金属络合物的转运; 5）磁共振成像剂; 6）金属离子、金属络合物和疟疾; 7）放射成像剂; 8）健康和疾病中的钒和铬，以及9）金属离子-核酸相互作用。这一主题的混合，这将通过一系列的研究讲座，旨在补充教程会议，以及通过海报会议覆盖。因此，预计目前的MIC-ACS研讨会将提供一个独特的机会，在一个充满机会和NIH使命中心的研究领域进一步发展。

项目成果

Supramolecular receptor design: anion-triggered binding of C60.

• DOI: 10.1002/anie.200602724
• 发表时间: 2006-10
• 期刊: Angewandte Chemie
• 作者: K. Nielsen;Won-seob Cho;G. Sarova;B. Petersen;A. Bond;J. Becher;F. Jensen;D. Guldi;J. Sessler;J. Jeppesen