Medicinal Inorganic Chemistry ACS Symposium F-2003

描述(由申请者提供)：申请资金用于支付参加药用无机化学(MIC)研讨会的部分旅费、注册费和当地费用，该研讨会将于2003年9月9日至11日在纽约举行的秋季美国化学学会(ACS)会议上举行。这是第一次此类研讨会，由美国化学学会无机化学和药物化学分部联合主办。它的目的是扩大和支持2002年7月在科尔比-索耶学院举行的新发起的戈登同名会议(MIC-GRC)，这些会议计划于2004年7月在同一地点举行。与MIC-GRC会议一样，MIC-ACS研讨会的目的是概述该领域的最新进展，从药物设计到开发再到临床试验，展示具有医学重要性的含金属系统的最新研究，并促进该领域新的合作研究努力的形成。特别是，MIC-GRC会议的目的是聚集知名专家进行高水平(和正式保密的)讨论，而本次MIC-ACS研讨会的一个主要目标是吸引新的研究人员到该领域，并使他们了解开展金属药物制剂研究所需的条件。因此，与MIC-GRC不同的是，MIC-ACS研讨会将以教程会议为特色，旨在展示将推定的金属基药物物质从实验室带到初步临床试验点所需的条件。本次研讨会要强调的具体专题包括：1)金属生成的自由基在健康和疾病中的作用；2)金属蛋白质与健康和疾病；3)作为药物靶标的金属蛋白质；4)金属和金属络合物的运输；5)磁共振成像剂；6)金属离子、金属络合物和疟疾；7)放射成像剂；8)钒和铬与健康和疾病；9)金属离子-核酸相互作用。这一主题的混合，将通过一系列旨在补充辅导课程的研究讲座以及海报课程来介绍。因此，预计本次MIC-ACS专题讨论会将提供一个独特的机会，在一个充满机会和对国家卫生研究院使命至关重要的研究领域进一步发展。

DESCRIPTION (provided by applicant): Funds are requested to defray in part the travel, registration, and local expenses of participants in the Medicinal Inorganic Chemistry (MIC) symposium to be held at the Fall American Chemical Society (ACS) meeting in New York, NY, September 9-11, 2003. This symposium, the first of its kind, is sponsored jointly by the Inorganic Chemistry and the Medicinal Chemistry Divisions of the ACS. It is intended to extend and support the newly initiated set of Gordon Conferences of the same name (MIC-GRC) that were inaugurated at Colby-Sawyer College in July 2002 and which are planned for the same venue in July of 2004. As has been true for the MIC-GRC meetings, the purpose of the MIC-ACS symposium is to outline the state-of-the-art in the field, from drug design to development to clinical trials, present up-to-the-minute research on metal-containing systems of medical importance, and foster the formation of new collaborative research efforts in the field. However, the symposium is designed to have a higher teaching component and be substantially more inclusive than the GRC's. In particular, whereas, the MIC-GRC meetings are designed to bring together established experts for high level (and formally confidential) discussions, a prime goal of the present MIC-ACS symposium is to attract new researchers to the area and provide them with an understanding of what is needed to conduct research on metal-based pharmaceutical agents. Thus, unlike the MIC-GRC, the MIC-ACS symposium will feature a tutorial session designed to show what is necessary to bring a putative metal-based drug substance from the laboratory to the point of initial clinical trials. Specific topics to be emphasized in this symposium include 1) the role of metal-generated radicals in health and disease; 2) metalloproteins in health and disease; 3) metalloproteins as drug targets; 4) transport of metals and metal complexes; 5) magnetic resonance imaging agents; 6) metal ions, metal complexes and malaria; 7) radioimaging agents; 8) vanadium and chromium in health and disease and, 9) metal ion-nucleic acid interactions. This mixture of topics, which will be covered through a series of research lectures designed to complement the tutorial session, as well as through poster sessions. It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission.