Hypothalamic Control of Food Intake and Body Weight

该计划项目旨在促进对控制食物摄入、体脂量和肥胖发病机制的生物系统的更好理解。虽然已经确定了许多关键分子和神经元细胞类型，但它们之间的相互作用以及环境因素对这些相互作用的影响最终决定了被保护的体脂水平。识别这些相互作用，并区分那些是关键的， 这一建议的总体重点是。由于这项工作本身的复杂性，实现这一目标的最佳办法是利用多学科方法和最先进的技术，将具有互补专长和资源的调查人员联合起来，进行有效和富有成效的合作。我们的建议将来自斯坦福大学医学院的Greg Barsh博士与华盛顿大学的NIH资助的研究人员Michael W.大卫·施瓦茨Cummings和Denis G.巴斯金--在三个高度相关的项目中，将阐明胰岛素、瘦素和饥饿素如何与营养相关信号相互作用，以调节摄食行为和下丘脑弓状核中关键神经元亚群的功能。每个项目的成功将取决于它们之间的相互作用以及组织化学核心和动物生理学核心提供的支持。整个计划项目的日常监督将由行政核心提供。在其资金的情况下，华盛顿大学医学院院长Paul Ramsey博士做出了新实验室空间的重大承诺，以支持这一奋进的成功。能源信号网络研究进展 体内平衡需要一个互动的，多学科的研究计划，并为正在进行的努力，以开发更有效的肥胖治疗策略是至关重要的。

This Program Project proposes to facilitate an improved understanding of biological systems governing food intake, body fat mass and obesity pathogenesis. While many key molecules and neuronal cell types have been identified, it is the interactions between them, and the impact of environmental factors on these interactions, that ultimately determine the level of body fat that is defended. Identifying these interactions, and distinguishing those that are critical from those that are not, provides the overarching focus of this proposal. Because of the complexity inherent in this undertaking, this goal is best met by uniting investigators with complementary expertise and resources in an effective and productive collaboration using a multidisciplinary approach and state-of-the-art technology. Our proposal brings Dr. Greg Barsh from Stanford University School of Medicine together with established, NIH-funded investigators at the University of Washington--Drs. Michael W. Schwartz, David E. Cummings and Denis G. Baskin--in three highly-interrelated Projects that will clarify how insulin, leptin and ghrelin interact with nutrient-related signals to regulate both feeding behavior and the function of key neuronal subsets in the hypothalamic arcuate nucleus. The success of each project will depend upon interactions between them and on support provided by a Histochemistry Core and an Animal Physiology Core. Day-to-day oversight of the entire Program Project will be provided by an Administrative Core. In the event of its funding, Dr. Paul Ramsey, Dean of the University of Washington School of Medicine, has made a major commitment of new laboratory space to support the success of this endeavor. Progress in understanding signaling networks in energy homeostasis requires an interactive, multidisciplinary research program and is critical for ongoing efforts to develop more effective strategies for obesity treatment.