Hypothalamic Control of Food Intake and Body Weight

下丘脑控制食物摄入量和体重

• 批准号: 8035572
• 负责人: Michael W Schwartz
• 金额: $ 27.34万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-25 至 2010-11-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8035572
• 关键词: Animals; Arts; Body Weight; Body fat; Collaborations; Eating; Environmental Risk Factor; Event; Feeding behaviors; Funding; Goals; Histocytochemistry; Homeostasis; Hypothalamic structure; Insulin; Interdisciplinary Study; Laboratories; Leptin; Neurons; Nutrient; Obesity; Pathogenesis; Physiology; Research Personnel; Resources; Signal Transduction; Structure of nucleus infundibularis hypothalami; Technology; Universities; Washington; biological systems; cell type; ghrelin; improved; interdisciplinary approach; medical schools; meetings; obesity treatment; programs; success

This Program Project proposes to facilitate an improved understanding of biological systems governing food intake, body fat mass and obesity pathogenesis. While many key molecules and neuronal cell types have been identified, it is the interactions between them, and the impact of environmental factors on these interactions, that ultimately determine the level of body fat that is defended. Identifying these interactions, and distinguishing those that are critical from those that are not, provides the overarching focus of this proposal. Because of the complexity inherent in this undertaking, this goal is best met by uniting investigators with complementary expertise and resources in an effective and productive collaboration using a multidisciplinary approach and state-of-the-art technology. Our proposal brings Dr. Greg Barsh from Stanford University School of Medicine together with established, NIH-funded investigators at the University of Washington--Drs. Michael W. Schwartz, David E. Cummings and Denis G. Baskin--in three highly-interrelated Projects that will clarify how insulin, leptin and ghrelin interact with nutrient-related signals to regulate both feeding behavior and the function of key neuronal subsets in the hypothalamic arcuate nucleus. The success of each project will depend upon interactions between them and on support provided by a Histochemistry Core and an Animal Physiology Core. Day-to-day oversight of the entire Program Project will be provided by an Administrative Core. In the event of its funding, Dr. Paul Ramsey, Dean of the University of Washington School of Medicine, has made a major commitment of new laboratory space to support the success of this endeavor. Progress in understanding signaling networks in energy homeostasis requires an interactive, multidisciplinary research program and is critical for ongoing efforts to develop more effective strategies for obesity treatment.

本项目旨在促进对控制食物摄入、体脂量和肥胖发病机制的生物系统的更好理解。虽然已经确定了许多关键分子和神经细胞类型，但它们之间的相互作用，以及环境因素对这些相互作用的影响，最终决定了被防御的体脂水平。识别这些相互作用，并区分哪些是关键的

项目成果

Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.

• DOI: 10.1007/s00125-009-1272-4
• 发表时间: 2009-05
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Sweet, I. R.;Gilbert, M.;Maloney, E.;Hockenbery, D. M.;Schwartz, M. W.;Kim, F.
• 通讯作者: Kim, F.