Perinatal Depression and Maternal Nutritional Status

描述(申请人提供)：围产期抑郁有严重的不良影响，包括损害母亲和儿童的营养状况。抑郁症状也可能受到营养不良的影响。这项建议的目标是为丽莎·博德纳尔博士提供所需的心理健康培训，使她成为围产期心理健康领域的独立调查员和营养干预者。博德纳博士是围产期领域的营养流行病学家。她对围产期精神病学营养方面的兴趣是她之前工作的自然延伸。她的短期目标是：(1)对用于评估精神健康结果的神经生物学、精神病学和方法学方法有明确的了解；(2)在诊断和评估女性情绪障碍的治疗反应方面获得实践经验；以及(3)获得试点数据，为R01拨款申请提供方法学上的严格方案，以对围产期情绪障碍的营养因素和后果进行大型前瞻性研究。她将通过一个包括指导、课程作业、临床实践、研讨会、定向阅读、手稿写作和负责任的研究行为培训的培训计划来实现这些目标。匹兹堡大学流行病学和精神病学系的机构支持将培养她发展成功竞争研究资金所需技能的能力。支持这些目标的项目将利用一项关于怀孕期间抑郁和抗抑郁药物使用后果的自然主义纵向研究(R01 MH60335；KL Wisner，PI)的数据，以：(1)确定接受抗抑郁药物治疗的抑郁症妇女及其子女的围产期营养状况，(2)更好地了解怀孕和产后体重与营养状况对抑郁症状的相互作用；(3)阐明营养在抑郁症的病理生理机制中的作用。

DESCRIPTION (provided by applicant): Perinatal depression has serious adverse effects, including harming the nutritional status of mothers and children. Depressive symptoms may also be affected by poor nutrition. The goal of this proposal is to provide Dr. Lisa Bodnar with the mental health training she needs to become an independent investigator and nutritional interventionist in perinatal mental health. Dr. Bodnar is a nutritional epidemiologist in the area of perinatology. Her interest in nutritional aspects of perinatal psychiatry represents a natural extension of her previous work. Her short-term goals are: (1) to acquire a clear understanding of neurobiology, psychiatry, and methodological approaches used to assess mental health outcomes; (2) to gain practical experience in the diagnosis and evaluation of treatment response of mood disorders in women; and (3) to obtain pilot data to inform a methodologically rigorous protocol for an R01 grant application to conduct a large prospective study of the nutritional contributors to and consequences of perinatal mood disorders. She will achieve these goals through a training plan that incorporates mentoring, coursework, a clinical practicum, seminars, directed readings, manuscript writing, and training in the responsible conduct of research. The institutional support of the epidemiology and psychiatry departments at the University of Pittsburgh will foster her ability to develop the skills necessary to successfully compete for research funding. The project to support these goals will use data from a naturalistic, longitudinal study (R01 MH60335; KL Wisner, PI) of the consequences of depression and antidepressant use during pregnancy to: (1) characterize the perinatal nutritional status of women with depression women treated with antidepressants for depression, and their offspring, (2) gain a greater understanding of the interaction of nutritional status and body weight during pregnancy and postpartum on depressive symptoms; and (3) elucidate the role of nutrition in the pathophysiology of depression.