Administrative Core

项目摘要 行政核心将协调和监督中心的所有活动。这将有助于最大限度地 互动和协同作用，并将能够最佳利用现有的研究基础设施，包括核心 资源和服务，以及最先进的高性能计算环境。它还将促进 Cast成员参与CSBC活动，确保CSBC的方案反馈 中心的业务整合，并管理为期一年的中心内部试点研究项目。一个 将建立有效的管理结构，以确保中心复杂目标的实现 包括一个执行指导委员会（ESC）-由中心主任、中心主任、 管理员、项目/核心领导和NCI项目官员-他们将监督中心的运作， 为研究者提供全面指导;一名中心管理员，经常与项目人员会面， 跟踪项目活动进展的核心线索，促进项目之间的互动和整合，以及 确保在ESC会议上做出的决定得到适当传达;以及一名数据经理， 确保对中心生成的资源和数据进行一致的注释和准备，以便提交 以及时有效的方式向NIH储存库提供。ESC将每季度召开一次会议， 进展，解决需要采取纠正措施的运营和研究问题，优先使用中心 资源，决定试点项目的奖励，并确保与相关的NCI和NIH的协调 活动行政核心将为年度NCI现场访问提供后勤支持，协调 准备进度报告，监控对监管要求的遵守情况，并及时提供财务报告。 审查和预算分析。为支持这些努力，核心小组将界定和跟踪一系列广泛的 定量指标，以评估中心交付成果的质量和效用。核心将负责 组建一个世界级的科学外部咨询委员会（EAB），为中心的联合主任提供建议， 对中心的研究项目进行公正的评估。除了特别通信外， EAB成员每年将在中心的NCI现场访问中亲自会面一次，在那里他们将参加科学研讨会。 项目和核心研究者的演讲，并将提供关于研究进展和未来的反馈 指导，以及对项目管理和试点项目管理的建议。的 行政核心将协调中心人员参与所有联盟活动，包括 参加会议和讲习班，为工作组和技术委员会作出贡献， 与其他国家卫生研究院的倡议。最后，它将支持通过外联方案实施的一项广泛的教育方案。 核心，旨在通过提供教育和学习来扩大癌症系统生物学的包容性和多样性 为来自纽约少数族裔服务机构的贫困高中生和大学生提供机会 市和其他大城市。

PROJECT SUMMARY The Administrative Core will provide coordination and oversight across all Center activities. It will help maximize interactions and synergies and will enable optimal use of available research infrastructure, including Core resources and services, and a state-of-the-art high-performance computing environment. It will also facilitate participation of CaST members to CSBC activities, ensure that programmatic feedback from the CSBC is integrated into the Center’s operations, and administer the one-year intra-Center pilot research projects. An effective management structure will be put in place to ensure that the Center’s complex objectives are achieved in timely fashion, including an Executive Steering Committee (ESC) —comprising the Center’s Directors, Center Administrator, Project/Core Leads, and NCI program officers—which will oversee the Center’s operations and provide overall guidance to the investigators; a Center Administrator who will meet frequently with Project and Core leads to track progress on project activities, facilitate interactions and integration between Projects, and ensure that the decisions made at the ESC meetings are properly communicated; and a Data Manager who will ensure that resources and data generated by the Center are consistently annotated and prepared for submission to NIH repositories in a timely and effective manner. The ESC will meet quarterly to candidly assess Project progress, address operational and research issues that require corrective action, prioritize use of Center resources, make decision about Pilot Project awards, and ensure coordination with related NCI and NIH activities. The Administrative Core will provide logistical support for the annual NCI site visit, coordinate preparation of progress reports, monitor compliance with regulatory requirements, and provide timely fiscal reviews and budget analysis. In support of these efforts, the Core will define and track a broad collection of quantitative metrics to assess the quality and utility of Center deliverables. The Core will be responsible for assembling a world class scientific External Advisory Committee (EAB) to advise the Center’s co-Directors and to provide an impartial assessment of the Center’s research program. In addition to ad hoc communications, the EAB members will meet in person once a year at the Center’s NCI site visit, where they will attend scientific presentations from Project and Core investigators and will offer feedback on research progress and future directions, as well as advice on program management and the administration of the Pilot Project program. The Administrative Core will coordinate the participation of Center personnel to all Consortium activities, including attending meetings and workshops, contributing to working groups and technical committees, and interfacing with other NIH initiatives. Finally, it will support a broad educational program implemented through the Outreach core, aiming to expand inclusivity and diversity in Cancer Systems Biology by offering education and learning opportunities to underprivileged high school and college students from minority-serving institutions in New York City and other big cities.