Administrative Core

摘要/总结：行政核心 我们提议的斯坦福大学癌症系统生物学中心（CCSB）的行政核心将提供 为与我们中心相关的所有协调活动提供后勤支持。它将在一个组织下运作， 促进我们研究中心所有组成部分之间的通信和访问的结构，其他NIH CSBC研究中心，NIH CSBC计划工作人员，以及拟议的U24协调中心。在内部， 我们的CCSB将有一个执行委员会、指导委员会和内部咨询委员会（IAB）来监督 我们中心的科学，培训和推广活动，并确保我们的总体目标和具体目标 正在被满足。我们的执行委员会将由我们的MPI领导，他们成功地领导了我们的CCSB计划 在我们的中心数据经理的支持下，沿着过去五年， 生物样本和数据核心的管理，并确保数据生成的全面管理， 处理和共享，以及我们的中心管理员，他们将监控和执行日常管理中心 运营我们的指导委员会将由核心领导和共同领导，项目领导和共同领导组成， 领导和数据中心经理。实验室将为我们的中心提供科学建议， 一般评估，并解决与我们的年度现场审查有关的具体问题。此外，我们将建立 一个由主要顾问组成的外部咨询委员会（EAB），以受益于他们在复杂的 转移进展中与肿瘤-免疫-基质相互作用相关的系统生物学问题。为了 扩大我们的研究者网络，我们的行政核心将促进我们提出的中心内试点项目 在第1-5年和跨联盟项目在第2-5年的计划。我们的行政核心将协调 招标、申请和审查程序。这些试点项目将根据以下因素进行评估和授予 科学价值，旨在培育与我们的科学主题相一致的新研究途径 研究中心跨联盟项目将获得资助，以增加研究机会， 合作体成员之间的协作和互动努力。行政核心将致力于 促进数据科学研究环境的公平、多样性和包容性，并提供培训 为少数民族和代表性不足的社区提供机会。最后，我们的行政核心将促进 年度科学审查进展的研究，培训，和推广目标的斯坦福大学CCSB由我们的 外部咨询委员会和国家癌症研究所。

ABSTRACT/SUMMARY: Administrative Core The Administrative Core of our proposed Stanford Center for Cancer Systems Biology (CCSB) will provide the logistical support for all coordinated activities related to our Center. It will operate under an organizational structure that facilitates communication and access across all components of our Research Center, other NIH CSBC Research Centers, the NIH CSBC Program staff, and the proposed U24 Coordinating Center. Internally, our CCSB will have an Executive Committee, Steering Committee, and Internal Advisory Board (IAB) to oversee the scientific, training, and outreach activities of our Center and ensure that our overall goals and specific aims are being met. Our Executive Committee will be led by our MPIs, who have successfully led our CCSB program over the past five years, along with the support of our Center Data Manager, who will oversee the coordination of the Biospecimen and Data Core and ensure overall management of data generation and pre- and post- processing and sharing, and our Center Administrator, who will monitor and execute daily administrative center operations. Our Steering Committee will be composed of the Core Leads and co-Leads, Project Leads and co- Leads, and the Data Center Manager. The IAB will be available to provide our Center with scientific advice, general evaluation, and address specific issues related to our annual site review. Additionally, we will establish an External Advisory Board (EAB) of key advisors to benefit from their extensive experience relevant to complex systems biology issues related to tumor-immune-stromal interactions in metastatic progression. In order to expand our network of investigators, our Administrative Core will facilitate our proposed Intra-center Pilot Project in Years 1-5 and Cross-Consortium Project in Years 2-5 of the program. Our Administrative Core will coordinate the solicitation, application and review processes. These pilot projects will be evaluated and awarded based on scientific merit with the aim of fostering new avenues of research aligned with the scientific theme of our Research Center. The cross-consortium projects will be funded to increase research opportunities for collaborative and interactive efforts among members of the consortium. The Administrative Core will commit to promoting equity, diversity, and inclusion in the data science research environment and provide training opportunities for minority and underrepresented communities. Finally, our Administrative Core will facilitate the annual Scientific Review of progress on the research, training, and outreach goals of the Stanford CCSB by our External Advisory Board and the National Cancer Institute.