Pilot / Exploratory Studies Core (PESC)

项目总结摘要-初步和探索性研究核心（PESC） 试点和探索性研究核心（PESC）的总体目标是促进创新和 有前途的研究，解决预测，结果和改善晚年残疾，特别是 在弱势群体中。这一更新申请建立在OAIC PESC成功的基础上， 在过去的9年里，我们支持了来自各个学术领域的学者，从 从住院医生到高级教员迄今为止，OAIC PESC学者的影响是巨大的， 超过一千六百万的联邦资金在这个周期中，我们特别关注 对初级教师过渡到独立和机会，以催化他们的未来的压力 OAIC主题领域的项目和职业发展。因此，我们将重点支持初级 已经获得K奖并准备向独立过渡的学者-即， 支持试点、探索性和初步研究，以促进第一个R01或同等的授予。我们将 此外，保持灵活性，优先考虑来自代表性不足背景的学者， 公平研究，尽管他们可能处于培训的早期阶段（即，pre-K）。PESC的具体目标 具体如下：（1）确定有前途的年轻学者感兴趣或致力于老龄化研究的重点 关于晚年残疾的医疗和社会决定因素，并支持他们从职业生涯过渡 开发奖励到R01/同等奖励，并提供试点和探索性资金;（2）整合培训 并支持PESC的活动（重点是K到R的过渡），与REC密切合作（ 专注于获得K奖），以制定一个无缝的支持计划， （3）为PESC学者提供研究设计，分析，招募和 通过使用OAIC核心，特别是数据， 分析核心（DAC）和脆弱老龄化研究核心（VARC）;（4）整合PESC研究和 来自UCSF临床和转化科学研究所（CTSI），该中心的资源学者 多样社区老龄化，弱势群体中心和其他相关资源 在加州大学旧金山分校;和（5）促进老龄化研究人员之间的多样性，通过提供具体的支持， 来自不同背景的试点奖候选人申请PESC资金。

PROJECT SUMMARY ABSTRACT – Pilot and Exploratory Studies Core (PESC) The overall goal of the Pilot and Exploratory Studies Core (PESC) is to promote innovative and promising research addressing the predictors, outcomes and amelioration of late-life disability, especially in vulnerable populations. This renewal application builds on the success of the OAIC PESC over the past 9 years in which we have supported scholars from across the academic spectrum of seniority, from residents to senior faculty. The impact of the OAIC PESC Scholars to date has been significant, resulting in over $16 million in federal funding. For this cycle, we are placing special attention on the intense pressures placed on junior faculty transitioning to independence and opportunities to catalyze their future projects and career growth in our OAIC theme area. As a result, we will focus on supporting junior scholars who already have a K award and are preparing for the transition to independence – namely, by supporting pilot, exploratory and preliminary studies to facilitate a first R01 or equivalent award. We will additionally maintain flexibility to prioritize scholars from underrepresented backgrounds interested in in equity research, though they may be at earlier stages in training (i.e., pre-K). The PESC specific aims are as follows: (1) Identify promising junior scholars interested in or committed to aging research focused on the medical and social determinants of late-life disability, and support their transition from career development awards to R01/equivalent awards with pilot and exploratory funding; (2) Integrate training and support activities of the PESC (which is focused on K to R transitions) closely with the REC (which is focused on obtaining K-awards) to develop a seamless program of support from pre-K fellows to Associate Professors; (3) Provide PESC Scholars support in study design, analysis, recruitment and retention of diverse and vulnerable populations through use of the OAIC Cores, specifically the Data and Analysis Core (DAC) and the Vulnerable Aging Research Core (VARC); (4) Integrate PESC studies and scholars with resources from the UCSF Clinical and Translational Science Institute (CTSI), the Center for Aging in Diverse Communities, the Center for Vulnerable Populations, and other relevant resources at UCSF; and (5) Promote diversity among researchers in aging, through offering specific support for pilot award candidates from diverse backgrounds who apply for PESC funding.