TASK ORDER 18 - SELF III

这项工作是对年轻非裔美国女性人群中子宫肌瘤危险因素的前瞻性研究--自我研究的继续。这项研究的三个主要假设是：(1)维生素D缺乏是肌瘤发病的风险因素；(2)生殖道感染是肌瘤发病的风险因素；(3)非洲血统比例较高是肌瘤发病的风险因素。两个第二假设包括(1)具有雌激素或孕激素样活性的化妆品会增加肌瘤的风险；(2)产前和早期接触(例如，早产、先兆子痫、大豆配方奶粉)会影响肌瘤的风险。 除了检验这些假设，这项研究还收集了广泛的信息，包括关于公认的风险因素的数据(例如，月经初潮年龄、孕产史、饮酒)、文献中风险估计不一致的常见暴露(例如，体重指数、口服避孕药的使用)、感兴趣的暴露(例如，饮食、锻炼)，以及详细的症状数据，特别是月经出血。

This work is a continuation of a prospective study of risk factors for fibroids in a population of young African-American women—the SELF Study. The study’s three primary hypotheses are: (1) vitamin D deficiency is a risk factor for fibroid incidence; (2) reproductive tract infection is a risk factor for fibroid incidence and; (3) a higher proportion of African ancestry is a risk factor for fibroid incidence. Two secondary hypotheses include (1) cosmetics with estrogenic or progestin-like activity increase the risk of fibroids and; (2) prenatal and early life exposures (e.g., preterm birth, preeclampsia, soy-based formula) influence risk of fibroids. In addition to testing these hypotheses, the study collected a broad spectrum of information including data on recognized risk factors (e.g., age of menarche, pregnancy history, alcohol use), common exposures with inconsistent risk estimates in the literature (e.g., body mass index, oral contraceptive use), exposures of interest for which there is very limited literature (e.g., diet, exercise), and detailed symptom data, especially menstrual bleeding.