BSL-3 Practices Core

BSL-3实践：摘要 BSL-3实践核心是满足乔治梅森大学（GMU）的生物医学 研究实验室（BRL）的使命是对新出现的传染性疾病进行开创性研究， 对大流行病的防范做出有意义的贡献，并随时准备及时应对 生物恐怖袭击或其他国家和全球紧急情况造成的传染病 病原体BRL作为科学合作中心，1）产生先进的 病原体生物学和宿主相互作用机制的知识，和2）评价诊断， 治疗剂和疫苗。为了满足使命，GMU必须有一个足够大的， 训练有素的劳动力，他们可以安全地进行高质量的工作，并符合联邦 法规;有效地操作先进的仪器;并生成可靠的数据，以支持 更快地将新发现转化为市场。 BRL具有强大的BSL-3实践核心，以确保持续安全地进行 在符合美国国立过敏研究院的高密封环境中进行研究， 传染病（NIAID），疾病控制中心（CDC）和美国卫生部 农业部（USDA）/动植物卫生检验局（APHIS）法规。 为病原体和选择性病原体研究创造和维持合规的工作环境 对实验室操作人员的健康和安全至关重要， exposure. GMU的BSL-3实践的实施战略的核心重点是： 通过提供一致的个性化课程来加强安全培训，2）实施 良好实验室规范（GLP），以提高研究质量和再现性，以及3） 确保BSL-3研究界能够有效地利用先进的研究成果 通过BRL经验丰富的成员的支持和培训， 研究团队。

BSL-3 PRACTICES: ABSTRACT The BSL-3 Practices core is critical for meeting George Mason University (GMU)’s Biomedical Research Lab (BRL)’s mission to perform groundbreaking research on emerging infectious diseases, contribute meaningfully to pandemic preparedness, and be poised to respond timely to a bioterrorist attack or other national and global emergencies caused by infectious pathogens. The BRL serves as a center for scientific collaboration to 1) generate advanced knowledge of pathogen biology and host interaction mechanisms, and 2) evaluate diagnostics, therapeutics and vaccines. To meet the mission, GMU must have an adequately sized and trained workforce who can conduct high quality work safely and in compliance with federal regulations; effectively operate advanced instrumentation; and generate reliable data to support faster transition of new discoveries to the market. It is critical that the BRL has a strong BSL-3 Practices core to ensure continued safe conduct of research in a high containment environment that complies with National Institutes of Allergy and Infectious Diseases (NIAID), Center for Disease Control (CDC), and US Department of Agriculture (USDA)/Animal and Plant Health and Inspection Service (APHIS) regulations. Creating and sustaining a compliant work environment for pathogen and select agent research is critical for the health and safety of laboratory operators and to prevent environmental exposure. The implementation strategies for GMU’s BSL-3 Practices core focus on 1) enhancing safety training by delivering a consistent, personalized curriculum, 2) implementing Good Laboratory Practices (GLP) to advance research quality and reproducibility, and 3) ensuring the BSL-3 research community can effectively utilize advanced research instrumentation through support and training by experienced members of the BRL applied research team.