CHOICES-TEEN: Efficacy of a Bundled Risk Reduction Intervention for Juvenile Justice Females

项目摘要/摘要 父母助学金：青少年年轻女性参与青少年司法环境 多种健康危险行为，使他们面临艾滋病毒/性传播疾病和怀孕的风险，受 酒精和大麻。这项研究的目的是测试选择青少年(CT)在减少 涉案青少年中物质暴露妊娠和艾滋病毒/性传播感染的风险 年轻女性。拟议的多样性补编：虽然司法的实质性部分-- 涉案的青春期年轻女性面临父母监禁，而这些 青少年使用药物和性行为的风险更高，现有的干预措施 因为高危青少年对那些父母被监禁的人影响有限 经历。这一多样性补充旨在确定CT对青少年的疗效 对有父母监禁经历的年轻女性进行额外的定量分析 由家长资助收集的数据，以及收集和分析来自 在最后9个月结束后有父母监禁经历的子样本 评估。具体地说，目标1将利用多水平逻辑回归分析和潜在 建立生长曲线模型以确定CT在降低风险方面的潜在区别疗效 在经历过父母教养的青春期年轻女性中SEP和HIV/STI的调查 监禁。在目标2中，将使用多层贝叶斯结构方程建模来 父母对CT作用机制的中介治疗效果评价 监禁。在目标3中，将对20名青少年进行定性访谈 妇女在干预臂中探索她们亲身经历的父母监禁 可能会影响CT的有效性和可接受性，并收集他们的适应建议。 拟议的多样性补充研究是家长补助金的自然延伸 同时为一位有前途的新研究员提供了一个新的机会，以启动一种新的 预防研究侧重于有父母监禁经历的青少年和 接受由经验丰富的研究人员组成的强大团队的指导。这份多元化副刊 将帮助应聘者获得干预研究的技能和经验，复杂的量化 临床试验数据分析、定性研究和稿件准备。此外，数据 这项研究将为K01应用程序开发新的或适应的干预措施(如 作为CT)，针对有父母监禁经历的青少年，长期目标是 在一项更大的R01研究中测试其有效性。这一多样性补充将大大有助于 这位候选人成为一名独立的NIH研究员的轨迹。

Project Summary/Abstract Parent Grant: Adolescent young women involved with juvenile justice settings engage in multiple health risk behaviors that place them at risk for HIV/STIs and pregnancy affected by alcohol and marijuana. This study aims to test the efficacy of CHOICES-TEEN (CT) in reducing the risks of substance-exposed pregnancy (SEP) and HIV/STIs among juvenile justice-involved young women. Proposed Diversity Supplement: While a substantive portion of justice- involved adolescent young women have been exposed to parental incarceration, and these adolescents were at higher risk of substance use and sexual risk behaviors, extant interventions for at-risk adolescents demonstrate limited effects on those with parental incarceration experiences. This diversity supplement aims to determine the efficacy of CT for adolescent young women with parental incarceration experiences by additional quantitative analyses of data collected by the parent grant and collection and analysis of qualitative interview data from a subsample with parental incarceration experiences following completion of the final 9-month assessment. Specifically, Aim 1 will utilize multilevel logistic regression analyses and latent growth curve modeling to determine the potential differential efficacy of CT in reducing the risks of SEP and HIV/STIs among adolescent young women who have experienced parental incarceration. In Aim 2, multilevel Bayesian structural equation modeling will be employed to evaluate the mediating treatment effects of the mechanisms of action for CT by parental incarceration. In Aim 3, qualitative interviews will be conducted with 20 adolescent young women in the intervention arm to explore their lived experiences of parental incarceration that may impact the efficacy and acceptability of CT and collect their suggestions for adaptations. The proposed diversity supplement research serves as a natural extension of the parent grant while offering a novel opportunity for a promising new investigator to initiate a new line of prevention research focused on adolescents with parental incarceration experiences and receive mentorship from a strong team of experienced researchers. This diversity supplement will help the candidate gain skills and experience in intervention research, complex quantitative analysis of clinical trial data, qualitative research, and manuscript preparation. Moreover, data from this study will inform a K01 application on developing new or adapted interventions (such as CT) for adolescents with parental incarceration experiences, with the long-term goal of testing its efficacy in a larger R01 study. This diversity supplement will significantly contribute to the candidate’s trajectory to becoming an independent NIH researcher.